紫外光谱相似度考察丹参粉针与6种常用输液的配伍稳定性研究

Study on Compatible Stability of Danshen Injection in six Transfusions by UV Similarity

目的:利用紫外光谱相似度考察注射用丹参粉针(冻干)与6种输液配伍后的稳定性。方法:模拟临床用药方法,将注射用丹参与氯化钠注射液(0.9%)、葡萄糖注射液(5%)、复方氯化钠注射液、复方右旋糖酐40注射液、右旋糖酐40葡萄糖注射液、果糖注射液配伍,测定配伍后7 h内配伍液的pH值及UV吸收度,根据UV吸收值计算紫外光谱相似度及其变化。结果:6种配伍液7 h内pH值无明显变化;在200 nm^400 nm范围内,注射用丹参与6种输液配伍的平均相似度大小依次为5%葡萄糖注射液>复方氯化钠注射液>0.9%氯化钠注射液>右旋糖酐40葡萄糖注射液>复方右旋糖酐40注射液>果糖注射液;配伍液在250.5~300 nm范围内相似度较大;配伍液相似度变化随时间延长逐渐减小。结论:注射用丹参与氯化钠注射液(0.9%)、葡萄糖注射液(5%)、复方氯化钠注射液配伍后较稳定;与右旋糖酐40葡萄糖注射液、复方右旋糖酐40注射液及果糖注射液输液配伍后相似度较小,应谨慎使用。

Objective： Applied UV similarity to study compatible stability of Danshen injection （Lyophilized Powder） in six transfusions Methods： Simulating the clinical usage, the pH of Danshen injection mixed with six transfusions and UV absorbability were determined in compatible solution within 7 hours, and then calculated the similarity on the basis of UV absorbability of compatible solution. Results ： There were no significant change in pH. The average similarity of six mixed transfusions in turn were 5% glucose in- jection, compound sodium chloride injection, 0. 9% sodium chloride injection, compound glucose dextran40 injection, compound saline dextran40 injection and fructose injection. The similarity was comparatively high between 250. 5 - 300nm . Conclusion： The similarity was relatively high when Danshen injection was mixed with 0. 9% sodium chloride injection, 5% glucose injection and compound sodium chloride injection within 7 hours. Compared with the above transfusions, the similarity of Danshen injection mixed with the other three transfusions was less high to mix cautiously.