枳实消痞汤治疗痰湿内阻型非酒精性单纯性脂肪肝临床研究

Effect of Zhishi Xiaopi Tang on Non-alcoholic Fatty Liver of Phlegm-Dampness Obstruction

目的:观察枳实消痞汤治疗痰湿内阻型非酒精性单纯性脂肪肝的临床疗效。方法:58例痰湿内阻型非酒精性单纯性脂肪肝患者随机分为治疗组(n=30)和对照组(n=28),治疗组口服枳实消痞汤12周,对照组口服多烯磷脂酰胆碱12周,观察治疗前后患者症状、血脂(TG、TC、HDL-C)、肝功能(ALT、AST、GGT)、体重指数(BMI)、腰臀比(WHR)。结果:治疗12周后,治疗组患者TG、TC、HDL-C、ALT、AST、GGT、BMI与对照组比较有统计学意义。结论:枳实消痞汤治疗可显著降低痰湿内阻型非酒精性单纯性脂肪肝患者的TG、TC、HDL-C水平,改善肝脏功能,使体重指数及腰臀围比降低,且未发现不良反应。

Objective ：To observe the effectiveness of Zhishi Xiaopi tang on non-alcoholic fatty liver of phlegm-dampness. Methods： The 30patients with non-alcoholic fatty liver of phlegm-dampness were given Zhishi Xiaopi tang compared with 28 patients receiving Polyene Phosphatidylcholine for 12 weeks. Recorded before and after treatment the patients＇ symptoms, blood fat （TG.TC.HDL-C）, liver func- tion （ ALT. AST. GGT）, body mass index （ BMI）, waist-to-hip ratio （WHR）. Results： After 12-week treatment, the treat group showed statistically different results of TG. TC. HDL-C. ALT. AST. GGT. BMI compared with those of the control group. Conclusion： Without signs of adverse effect, Zhishi Xiaopi tang significantly lowered the levels of TG.TC.HDL-C, improved liver functions, and reduced BMI and WHR for patients with non-alcoholic fatty liver of phlegm-dampness.