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PTEN基因与结直肠癌发生发展侵袭转移关系的研究 被引量：1

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摘要 目的探讨PTEN基因与结直肠癌发生、发展,侵袭转移的关系。方法结直肠癌手术切除标本96例,采用免疫组化SABC法染色检测。结果结直肠癌患者PTEN基因总阳性率为52.1%(50/96),癌旁组织中阳性率为80.4%(37/46),结直肠癌表达与患者年龄,性别,肿瘤大小无关,与结直肠癌组织学病理分级,Dukes分级及有无淋巴结的转移关系密切。结论PTEN基因在结直肠癌的发生、发展、侵袭转移过程中起抑制作用。
作者 刘国平 何雄文 牛美兰
机构地区 河南省中医药研究院附属医院外科 黄河科技学院
出处 《医药论坛杂志》 2009年第17期44-45,共2页 Journal of Medical Forum
关键词 PTEN 结直肠癌 发展 侵袭 转移
分类号 R735.3 [医药卫生—肿瘤]
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医药论坛杂志
2009年 第17期

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