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肝癌组织中p57^kip2基因表达缺失与甲基化的关系 被引量：2

Relationship between DNA methylation and expressions of p57^kip2 in hepatocellular carcinoma
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摘要 p57^kip2属于CIP／KIP家族成员，抑制细胞周期从G1期到S期转化，使细胞周期停滞在G1期，进而阻止细胞增殖。肝癌组织中普遍存在p57^kip2mRNA表达水平的下降，提示p57^kip2与肝癌发生关系密切。本研究采用原位分子杂交和甲基化特异性PCR方法检测p57^kip2 mRNA的表达及启动子区甲基化情况，探讨p57^kip2基因失表达机制。
作者 赵继智 章宗籍 申丽娟 程若川 张华献 钱忠义
机构地区 昆明医学院病理教研室 昆明医学院第一附属医院外科
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2009年第9期703-704,共2页 Chinese Journal of Hepatology
基金 云南省自然科学基金（2005C0045M）
关键词 癌 肝细胞 DNA甲基化 有丝分裂抑制因子 Carcinoma, hepatocellular DNA methylation p57^kip2
分类号 R735.7 [医药卫生—肿瘤]
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共引文献44

同被引文献7

  • 1Ke-JunNan,HuiGuo,Zhi-PingRuan,ZhaoJing,Shaan-XiLiu.Expression of p57^(kip2) and its relationship with clinicopathology, PCNA and p53 in primary hepatocellular carcinoma[J].World Journal of Gastroenterology,2005,11(8):1237-1240. 被引量：20
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中华肝脏病杂志
2009年 第9期

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