摘要
目的:检测雌激素受体(ER)和孕激素受体(PR)在单发与多发(肿瘤个数≥2个)乳腺纤维腺瘤中的表达,观察单发与多发乳腺纤维腺瘤复发率的差异,探索减少复发的方法。方法:100例单发与100例多发乳腺纤维腺瘤光学显微镜下观察并对肿瘤组织进行ER、PR免疫组织化学染色。对多发者中50例术后予以三苯氧胺治疗(治疗组)。结果:ER在单发纤维腺瘤与多发纤维腺瘤中的表达阳性率分别为65%和80%(P<0.05),PR在单发纤维腺瘤与多发纤维腺瘤中的表达阳性率分别为54%和63%(P>0.05)。术后3年,100例多发乳腺纤维腺瘤中治疗组50例无复发,非治疗组50例有12例复发(P<0.05);而100例单发者中6例复发(P<0.05)。结论:多发纤维腺瘤的ER表达阳性率高于单发者,多发纤维腺瘤的复发率高于单发者,多发纤维腺瘤术后予以三苯氧胺治疗可以降低复发率。
Objective： To detect the expressions of estrogen receptor（ER）, progestogen receptor （PR） in single and multiple breast fibroadenoma tissue and to observe the differences of the recrudescence rate between single and multiple fibroadenoma tissue. Methods： One hundred cases of single breast fibroadenoma and 100 cases of multiple breast fibroadenoma were retrospectively observed under the light microscope, and immunohistochemical staining was performed for ER, PR in tumor tissues. Results： Positive expression rates for ER in single and multiple fibroadenoma tissue were 65% and 80% （P〈0.05）. Positive expression rates for PR in single and multiple fibroadenoma tissue were 54% and 63% （P〉0.05）. Three years after operation, there were 29 recrudescent cases in 100 cases of multiple fibroadenoma,and 6 recrudescent cases in 100 cases of single fibroadenoma （P〈0.05）. Conclusion： The ER-positive rate of multiple fibroadenoma is higher than single patients. The recrudescence rate of multiple fibroadenoma is higher than single patients.
出处
《中国现代普通外科进展》
CAS
2009年第8期686-687,712,共3页
Chinese Journal of Current Advances in General Surgery
关键词
乳腺肿瘤
纤维腺瘤
受体
雌激素
孕激素
Breast neoplesms
Fibroadenoma
Receptor estrogen
Receptor
progestogen
