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Toll样受体对肠屏障是起保护作用还是损害作用 被引量：3

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摘要 在植物、无脊椎动物和脊椎动物中。存在着一类高度保守的受体家族-Toll样受体（toll—likereceptors，TLRs），具有重要的生理和病理作用。TLRs广泛分布在人类各种组织和细胞中，尤其是在呼吸道、泌尿道、肠道和免疫细胞表面。
作者 李国逊 李宁
机构地区 南京军区南京总医院全军普通外科研究所
出处 《中华胃肠外科杂志》 CAS 北大核心 2009年第5期540-541,共2页 Chinese Journal of Gastrointestinal Surgery
关键词 TOLL样受体 损害作用 保护作用 肠屏障 无脊椎动物 细胞表面 受体家族 病理作用
分类号 R3 [医药卫生—基础医学]
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参考文献16

  • 1Vora P,Youdim A,Thomas LS,et al.Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells.J Immunol,2004,173(9):5398-5405.
  • 2Lundin A,Bok CM,Aronsson L,et al.Gut flora,Toll-like receptors and nuclear receptors:a tripartite communication that tunes innate immunity in large intestine.Cell Microbiol,2008,10(5):1093-1103.
  • 3Chen J,Rao JN,Zou T,et al.Polyamines are required for expression of Toll-like receptor 2 modulating intestinal epithelial barrier integrity.Am J Physiol Gastrointest Liver Physiol,2007,293(3):G568-G576.
  • 4Neish AS.TLRS in the gut.Ⅱ.Flagellin-induced inflammation and antiapoptosis.Am J Physiol Gastrointest Liver Physiol,2007,292(2):G462-G466.
  • 5Cario E,Gerken G,Podolsky DK.Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function.Gastroenterology,2007,132(4):1359-1374.
  • 6Fukata M,Michelsen KS,Eri R,et al.Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis.Am J Physiol Gastrointest Liver Physiol,2005,288(5):G1055-G1065.
  • 7Vijay-Kumar M,Sanders CJ,Taylor RT,et al.Deletion of TLR5 results in spontaneous colitis in mice.J Clin Invest,2007,117(12):3909-3921.
  • 8Zhang Z,Schluesener HJ.Mammalian toll-like receptors:from endogenous ligands to tissue regeneration.Cell Mol Life Sci,2006,63(24):2901-2907.
  • 9Chen LW,Chang WJ,Chen PH,et al.TLR ligand decreases mesenteric ischemia and reperfusion injury-induced gut damage through TNF-alpha signaling.Shock,2008,30(5):563-570.
  • 10Hausmann M,Kiessling S,Mestermann S,et al.Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation.Gastroenterology,2002,122(7):1987-2000.

同被引文献25

  • 1Fei LI Hua-dong WANG Da-xiang LU Yan-ping WANG Ren-bin QI Yong-mei FU Chu-jie LI.Neutral sulfate berberine modulates cytokine secretion and increases survival in endotoxemic mice[J].Acta Pharmacologica Sinica,2006,27(9):1199-1205. 被引量：24
  • 2Livak K J, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2 ( -Delta Delta C (T) Method. Methods ,2001,25 (4) :402-408.
  • 3Yu M, Shao D, Yang J, et al. Ketamine suppresses intestinal TLR4 expression and NF-kappaB activity in lipopolysaccharide-treated rats. Croat Med J,2006,47(6) :825-831.
  • 4Liu Z, Yu Y, Jiang Y, et al. Growth hormone increases lung NF- kappaB activation and lung microvascular injury induced by lipopolysaccharide in rats. Ann Clin Lab Sci, 2002,32 ( 2 ) : 164- 170.
  • 5Clark JA, Gan H, Samocha A J, et al. Enterocyte-specific epider- mal growth factor prevents barrier dysfunction and improves mortality in routine peritonitis. Am J Physiol Gastrointest Liver Physiol,2009,297 ( 3 ) : G471-479.
  • 6Vaishnava S, Behrendt CL, Ismail AS, et al. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci USA, 2008, 105 (52) :20858-20g63.
  • 7Chen J, Rao JN, Zou T, et al. Polyamines are required for expression of Toll-like receptor 2 modulating intestinal epithelial barrier integrity. Am J Physiol Gastrointest Liver Physio1,2007,293 (3) : G568-576.
  • 8Cario E, Gerken G, Podolsky DK. Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology,2007,132 ( 4 ) : 1359 -1374.
  • 9Yu M,Shao D,Lin J,et al. Effects of ketamine on levels of cytokines, NF-kappaB and TLRs in rat intestine during CLP-induced sepsis. Int Immunopharmacol JT-International Immunopharmacology,2007,7(8) :1076-1082.
  • 10Shang L, Fukata M, Thirunarayanan N, et al. Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria. Gastroenterology JT- Gastroenterology,2008,135 ( 2 ) : 529 -538.

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中华胃肠外科杂志
2009年 第5期

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