百令胶囊联合贝那普利对早期糖尿病肾病患者尿白蛋白排泄率及C反应蛋白的影响

Effect of Combined Therapy with Bailing Capsule and Benazepril on Urinary Albumin Excretion Rate and C-reactive Protein in Patients with Early Diabetic Nephropathy

目的观察百令胶囊联合贝那普利对糖尿病患者尿白蛋白排泄率(UAER)及C反应蛋白(CRP)水平的影响,探讨其对早期糖尿病肾病的保护作用。方法60例2型早期糖尿病肾病患者,随机分为对照组(贝那普利组)、治疗组(百令胶囊联合贝那普利组),经16周治疗后,观察UAER和CRP水平的变化,评价百令胶囊联合贝那普利的肾脏保护作用。结果对照组治疗前24 h尿蛋白、UAER及CRP分别为(0.85±0.32)g/24 h,(83.34±38.27)μg/min,(2.67±1.72)mg/L,治疗后分别为:(0.43±0.17)g/24 h,(71.22±31.12)μg/min,(1.05±0.78)mg/L,治疗组治疗前分别为:(0.87±0.31)g/24 h,(81.59±35.69)μg/min,(2.55±1.66)mg/L,治疗后分别为:(0.25±0.29)g/24 h,(57.32±31.11)μg/min,(0.49±0.38)mg/L;两组治疗后24 h尿蛋白、UAER、CRP均降低,与本组治疗前比较,差异有统计学意义(P<0.05,P<0.01),治疗组较对照组降低更显著(P<0.01)。两组治疗后血清肌酐(SCr)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)较治疗前略有下降,差异无统计学意义(P>0.05)。结论百令胶囊联合贝那普利明显降低早期糖尿病肾病患者UAER及CRP的水平,使肾脏损伤程度减低,较单用贝那普利作用明显。

Objective To observe the effect of combined therapy with Bailing Capsule（BC） and benazepril on the levels of urinary albumin excretion rate（UAER） and C-reactive protein（CRP） for exploring its protective effect on early diabetic nephropathy.Methods Sixty patients with early diabetic nephropathy were randomly assigned to the control group treated by benazepril alone,and the treated group treated by BC and benazepril,and the treatment lasted for 16 weeks.The changes of UAER and CRP levels were measured to estimate the protective effect of the combined therapy.Results Levels of 24h urinary protein,UAER,CRP were（0.85±0.32）g/24 h,（83.34±38.27）μg/min,（2.67±1.72）mg/L before treatment in the control group,and（0.43±0.17）g/24 h,（71.22±31.12）μg/min,（1.05±0.78）mg/L after treatment and they were（0.87±0.31）g/24 h,（81.59±35.69）μg/min,（2.55±1.66）mg/L before treatment in treated group,and（0.25±0.29）g/24 h,（57.32±31.11）μg/min,（0.49±0.38）mg/L after treatment recpectively,all of them decreased after treatment in both groups,showing significant differences as compared with those before treatment（P〈0.05,P〈0.01）,and the reduction in the treated group was more significant（P〈0.01）;meanwhile,levels of serum creatinine,fasting blood glucose and HbA1c had somewhat decrease,showing no statistical difference with those before treatment（P〉0.05）.Conclusion Combined use of BC and benazepril could significantly lower the UAER and CRP levels in patients with early diabetic nephropathy to alleviate the renal impairment,showing an effect better than that of using benazepril alone.