血浆脂联素在冠心病患者中的变化及其临床意义

Clinical significance of the changes of plasma adiponectin levels in patients with coronary artery disease

目的:观察冠心病患者血浆脂联素(APN)水平,及血浆APN水平与急性冠状动脉综合征(ACS)之间的关系。方法:经冠状动脉造影证实的冠心病患者共110例,其中稳定型心绞痛组35例,不稳定型心绞痛组42组,急性心肌梗死组33例,并且选取20例正常健康人作为对照组。采用ELISA法检测血浆APN水平,同时检测各组生化指标,如空腹血糖、TC、TG、LDL-C、HDL-C等。结果:急性心肌梗死组、不稳定型心绞痛组中血浆APN浓度显著低于稳定型心绞痛以及对照组。logistic多元逐步分析显示吸烟、空腹血糖以及低血浆APN浓度与ACS发生独立相关。结论:血浆APN可能是评估冠心病的新的独立危险因素,可能与ACS的发生有关。

Objective：To observe the plasma adiponectin leves in patients with coronary artery disease（CAD） and evaluate the relationship between adiponectin and the development of acute coronary syndrome（ACS）.Method：A total of 110 CAD patients conformed by coronary angiography were divided into stable angina pectoris （SAP）（n=35）,unstable angina pectoris（UAP）（n=42） and acute myocardial infartion （AMI）group （n=33）,while 20 healthy adults were selected as control group. Plasma adiponectin levels were measured by ELISA,and others by routine method. Rusult：Plasma adiponectin levels in patients with AMI or UAP were significantly lower than in patients with SAP and control. Multiple logistic regression analysis showed that smoking,fasting blood glucose,and low plasma adiponectin concentrations correlated independently with the development of ACS. Conclusion：Measurement of plasma adiponection may be used for assessing the risk of CAD and may be related to the development of ACS.