期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

骨吸收与骨形成耦联中Eph/ephrin信号转导的研究进展 被引量：4

Progress in Researches of Eph/ephrin Signaling in Coupling of Bone Resorption and Bone Formation
下载PDF
导出
摘要 破骨细胞的骨吸收活动与成骨细胞的骨形成活动相互作用调节,形成一种特殊的耦联机制,影响骨骼生长、发育及正常骨组织结构的维持.最近几年提出的Eph/ephrin双向信号转导在骨吸收与骨形成耦联中的研究越来越受到关注.从Eph/ephrin分子结构、信号转导机制及生物学意义等几方面对该理论作一阐述. Osteoclastic bone resorption and osteoblastic to effect the development of bone and to maintain bone bone formation are coordinated as a coupled mechanism homeostasis. Recently reported Eph/ephrin bidirectional signaling between osteoclasts and osteoblasts plays a pivol role in bone homeostasis and casts new light on coupling of bone resorption and bone formation, which is gaining more and more attention in researches of bone biology and bone diseases. The present article aims to address the researches on the Eph/ephrin bidirectional signaling between osteoblasts and osteoclasts with molecular constitution, mechanism of the signal transduction, biological significance and so on.
作者 赵鹃 毛英杰 谷志远
机构地区 浙江大学医学院附属口腔医院
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2009年第9期1101-1105,共5页 Progress In Biochemistry and Biophysics
基金 国家自然科学基金(30700958) 浙江省医药卫生科学研究基金(2007A131)资助项目~~
关键词 破骨细胞 成骨细胞 EPH EPHRIN 双向信号转导 osteoclasts, osteoblasts, Eph receptors, ephrin ligands, bidirectional signal transduction
分类号 R68 [医药卫生—骨科学] R780.2 [医药卫生—口腔医学]
  • 相关文献

参考文献30

  • 1Matsuo K, Irie N. Osteoclast-osteoblast communication. Arch Biochem Biophys, 2008, 473(2): 201 -209.
  • 2Wakeyama H, Akiyama T, Takahashi K, et al. Negative feedback loop in the Bim-caspase-3 axis regulating apoptosis and activity of osteoclasts. J Bone Miner Res, 2007, 22(10): 1631 - 1639.
  • 3Nakamura T, Imai Y, Matsumoto T, et al. Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell, 2007, 130(5): 811 -823.
  • 4Mundy G R, Elefteriou F. Boning up on ephrin signaling. Cell, 2006, 126(3): 441 -443.
  • 5Edwards C M, Mundy G R. Eph receptors and ephrin signaling pathways: a role in bone homeostasis. Int J Med Sei, 2008, 5(5): 263 -272.
  • 6Ryu J, Kim H J, Chang E J, et al. Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling. EMBO J, 2006, 25 (24): 5840-5851.
  • 7Sullivan S O, Naot D, Callon K, et al.Imatinib promotes ostenblast differentiation by inhibiting PDGFR signaling and inhibits osteoclastogenesis by both direct and stromal cell-dependent mechanisms. J Bone Miner Res, 2007, 22 (11): 1679- 1689.
  • 8Zhao C, Irie N, Takada Y, et al. Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab, 2006, 4(2): 111-121.
  • 9王琳,郑国光.Eph-ephrin介导反向信号传递的研究进展[J].生物化学与生物物理进展,2007,34(11):1142-1146. 被引量：4
  • 10Pasquale E B. Eph receptor signalling casts a wide net on cell behaviour. Nat Rev Mol Cell Biol, 2005, 6(6): 462-475.

二级参考文献32

  • 1Hirai H,Maru Y,Hagiwara K,et al.A novelputative tyrosine kinase receptor encoded by the Eph gene.Science,1987,238 (4834):1717-1720
  • 2Himanen J P,Nikolov D B.Eph receptors and ephrins.Int J Biochem Cell Biol,2003,35(2):130- 134
  • 3Himanen J P,Chumley M J,Lackmann M,et al.Repelling class discrimination:Ephrin-A5 binds to and activates ephB2 receptor signaling.Nat Neuro Sci,2004,7(5):501-509
  • 4Nakada M,Niska J A,Tran N L,et al.EphB2/r-ras signaling regulates glioma cell adhesion,growth,and invasion.Am J Pathol,2005,167(2):565-576
  • 5Lawrenson I,Wimmer-Kleikamp S H,Lock P,et al.Ephrin-A5 induces rounding,blebbing and de-adhesion of ephA3-expressing 293T and melanoma cells by CrkⅡ and Rho-mediated signalling.J Cell Sci,2002,115(Pt5):1059- 1072
  • 6Carter N,Nakamoto T,Hirai H,et al.Ephrin-A1 induced cytoskeletal re-organization requires Fak and p130 (cas).Nat Cell Biol,2002,4(8):565-573
  • 7Prevost N,Woulfe D S,Tognolini M,et al.Signaling by ephrinB1 and Eph kinases in platelets promotes Rap1 activation,platelet adhesion,and aggregation via effector pathways that do not require phosphorylation of ephrinB1.Blood,2004,103(4):1348- 1355
  • 8Kullander K,Klein R.Mechanisms and functions of eph and ephrin signaling.Nat Rev Mol Cell Biol,2002,3(7):475-486
  • 9Mundy G R,Elefteriou F.Boning up on ephrin signaling.Cell,2006,126(3):441 -443
  • 10Surawska H,Ma P C,Salgia R.The role of ephrins and Eph receptors in cancer.Cytokine Growth Factor Rev,2004,15 (6):419-433

共引文献3

同被引文献36

  • 1陈克明,葛宝丰,马慧萍,白孟海,王勇,刘剑梅,高梅.淫羊藿总黄酮对切除卵巢大鼠发生骨质疏松症的抑制作用(英文)[J].中国临床康复,2004,8(26):5681-5683. 被引量：14
  • 2Zhao C, Irie N, Takada Y, et al. Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metabolism, 2006, 4(2): 111-121.
  • 3Palmer A, Klein R. Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function. Genes & Development, 2003, 17(12): 1429-1450.
  • 4Manolagas S C. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocrine Reviews, 2000, 21(2): 115 137.
  • 5Boyle W J, Simonet W S, Lacey D L. Osteoclast differentiation and activation. Nature, 2003, 423(6937): 337-342.
  • 6Karsenty G, Wagner E F. Reaching a genetic and molecular understanding of skeletal development. Developmental Cell, 2002, 2(4): 389-406.
  • 7Wada T, Nakashima T, Hiroshi N, et cd. RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends in Molecular Medicine, 2006, 12(1): 17-25.
  • 8Grootjans J J, Reekmans G, Ceulemans H, et al. Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of syntenin. J Biol Chem, 2000, 275(26): 19933- 19941.
  • 9Dev K K. PDZ domain protein-protein interactions: a case study with PICK1. Current Topics in Medicinal Chemistry, 2007, 7(1): 3 20.
  • 10Mundy G R, Elefteriou F. Boning up on ephrin signaling. Cell, 2006, 126(3): 441-443.

引证文献4

二级引证文献8

生物化学与生物物理进展
2009年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部