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两种类型抑郁症大鼠海马及血清内脑源性神经营养因子水平的比较 被引量：2

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摘要 目的比较应用两种方法制备的抑郁症大鼠模型血清及海马内脑源性神经营养因子(BDNF)水平的改变,为抑郁症的诊断及治疗机制的研究奠定基础。方法应用慢性温和性刺激制备外源性抑郁症大鼠模型,通过在出生第8天的幼鼠腹腔注射五羟色胺再摄取抑制剂-氯米帕明制备成年内源性抑郁症大鼠模型。应用ELISA和免疫组织化学方法检测血清及海马内BDNF水平。结果两种模型抑郁症大鼠的蔗糖摄取量与正常对照组相比均明显减少(P<0.01);与正常对照组相比,两种抑郁症大鼠血清BDNF水平明显降低(P<0.01),而两种抑郁症大鼠血清BDNF水平则无显著差异(P>0.05);内源性及外源性抑郁症大鼠海马内BDNF阳性细胞数与正常组大鼠相比均降低(P<0.05),但内源性抑郁症大鼠海马内BDNF阳性细胞数降低尤为明显(P<0.01)。结论内外源性抑郁症大鼠脑内BDNF水平均较正常组大鼠明显降低,但内源性抑郁症大鼠BDNF减少尤其明显。海马内BDNF水平的降低可能是造成抑郁症患者认知和记忆功能障碍的原因之一。
作者 胡荫 尹维刚 林荣 王力
机构地区 宁波大学医学院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2009年第17期2188-2190,共3页 Chinese Journal of Gerontology
基金 浙江省实验动物科技计划资助项目(2007F80017)
关键词 抑郁症 脑源性神经营养因子 海马 大鼠
分类号 R749.4 [医药卫生—神经病学与精神病学]
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参考文献12

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共引文献30

同被引文献25

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二级引证文献12

中国老年学杂志
2009年 第17期

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