天疱疮43例临床资料分析

Clinical Analysis of 43 Patients with Pemphigus

目的探讨天疱疮各型的临床特征和治疗方法。方法对43例天疱疮住院患者的临床资料进行回顾性分析。结果35.71%的寻常型天疱疮患者出现口腔、外阴黏膜损害,14.29%红斑型天疱疮患者出现口腔溃疡,1例增殖性天疱疮患者表现为近3年口腔黏膜破溃。直接免疫荧光确诊阳性72.72%。糖皮质激素治疗为首选,糖皮质激素联合免疫抑制剂治疗疗效好。结论直接免疫荧光为诊断天疱疮的常用方法,天疱疮的分型是影响激素用量的重要因素,糖皮质激素联合免疫抑制剂是目前治疗此病的主要方法。

Objective To characterize the clinical features and to evaluate the treatment options in patients with pemphigns. Methods The clinical date from 55 in-patients with pemphigus were analyzed retrospectively. Results 35.71% of pemphigns vulgnris were affected with dental ulcer or uleus vulvae;14.29% of pemphigus erythematosus were affected with dental ulcer;Only one patient had the manifestations of dental ulcer for 3 years Direct immunofluorescence test showed positive in 72.72% patients Corticosteroid was the first choice of the management for pemphigus, and most of patients got alleviation after the treatment of corticosteroid combined with immunosuppressives. Conclusion Direct immunofluorescence is useful technology in diagnosis of pemphigns, and the classification of pemphigns is the key factor influencing appropriate doses of corticosteroid for pemphigns. Corticosteroid combined with immunosuppressives was the mainstay of treatment of oemohigus.