播散性浅表性光化性汗孔角化症并发鳞状细胞癌1例

A Case of Disseminated Superficial Actinic Porokeratosis combined with Squamous Cell Carcinoma

患者男,55岁。全身泛发环状丘疹,中央呈轻度萎缩,边缘呈堤状隆起的棕色皮损40年,3年前左踝部出现一菜花样增生,反复多次发生溃疡。左踝增生处皮损组织病理:表皮可见两个充满角蛋的凹陷及角化不全柱,下方颗粒层消失,棘层肥厚:真皮内大量鳞状细胞团块,小血管周围大量以淋巴细胞为主的单核细胞浸润。诊断:播散性浅表性光化性汗孔角化症;鳞状细胞癌。本病属常染色体显性遗传,有恶变倾向。

A case of disseminated superficial actinic porokeratosis combined with squamous cell carcinoma was reported. The patient, male, 55-year-old, presented with generalized annular brown dermal injure, characterized by light dermal atrophy in the centre with dam-like eminence around it, on his whole body for 40 years. There was a cauliflower-like proliferation and ulceration on his left ankle in the recent 3 years, which was diagnosed as disseminated superficial actinic porokeratosis combined with squamous cell carcinoma. Disseminated superficial actinic porokeratosis was an autosomal dominant disease and inclinable to be malignant.