雌激素对表皮功能的调节作用

Regulation of Estrogen on Epidermal Function

除真皮、皮脂腺及毛囊外,表皮也是雌激素作用的主要器官之一。雌激素受体广泛地分布于角质形成细胞中;临床上,雌激素水平的降低可导致皮肤干燥和萎缩;妊娠期银屑病减轻,而产后则加重。雌激素对外伤的愈合及色素的生成有促进作用。此外,雌激素与皮肤黑素瘤及角质形成细胞的增生也有明显的关系。因此,进一步了解雌激素对皮肤功能的调节作用有助于对某些皮肤病的诊断、预防和治疗。

Objective Estrogen plays an important role on epidermal function as well as on dermis, sebaceous gland, and hair follicles, etc. Estrogen receptors are expressed in keratinocytes. Clinically, skin dryness and atrophy could be attributed to the reduction of estrogen level. Psoriasis is improved during pregnancy and worsen postpartum. Estrogen accelerated wound healing and melanin production. Additionally, melanoma cell and keratinocyte proliferations are also regulated by estrogen. Thus, to further understand the regulatory effects of estrogen on cutaneous function would be helpful in diagnosis, prevention and treatment of some skin disorders.