阿苯哒唑对蚯蚓的生态毒理效应

Ecotoxicolgical effects of albendazole on Eisenia fetida

采用人工污染土壤法测定了不同浓度阿苯哒唑对蚯蚓生长、生存、繁殖以及超氧化物歧化酶(SOD)、谷胱甘肽-硫转移酶(GST-S)、乙酰胆碱酯酶(AchE)活性的影响.结果表明:低浓度阿苯哒唑(5mg·kg-1)对蚯蚓的繁殖有显著的抑制作用(P<0.05);当阿苯哒唑含量达到7mg·kg-1时,将明显影响蚯蚓的生长和生存(P<0.05);当其含量达到10mg·kg-1时,蚯蚓的死亡率为53%.阿苯哒唑浓度与蚯蚓的生长、繁殖间存在明显的剂-效关系.阿苯哒唑染毒21d后,对蚯蚓SOD、GST-S的活性有明显影响,药物浓度与效应间没有明显的剂-效关系,对AchE活性没有表现出明显的影响.阿苯哒唑对土壤动物显示毒性作用,具有潜在的生态风险.

By using artificial soil test, the effects of different concentration albendozole on Eisenia foetida＇s growth, survival, reproduction, and＇activities of superoxide dismutase （SOD）, glutathi-one-sulfurtransferase （GST-S） and acetylcholine esterase （AchE） were studied. Low concentration （5 mg·kg^-1 ） albendazole inhibited the reproduction of E. foetida significantly （P 〈 0.05）, and 7 mg·kg^-1 of albendazole had significant effects on the growth and survival of E. foetida. When the albendazole concentration reached to 10 mg·kg^-1, the mortality of E. foetida was as high as 53%. There was a significant dose-response relationship between the exposure concentration of albendazole and the inhibition rate of E. foetida＇ s growth and reproduction. After 21 days＇ albendazole exposure, the SOD and GST-S activities were affected significantly, but no significant doseresponse relationship was observed. Albendazole exposure had less effects on AchE activity. In sum, albendazole had direct toxicity on soil animals, with a potential ecological risk.