慢性胃炎患者胃内pH值相关因素分析

Analysis of Factors Related with Gastric pH Value in Patients with Chronic Gastritis

背景:传统观点认为胃酸分泌随年龄增加和胃黏膜萎缩而减少,但也有研究持不同观点。目的:研究慢性胃炎患者胃内pH值与性别、年龄、糖尿病、萎缩和幽门螺杆菌(H.pylori)感染之间的相关性。方法:共纳入67例慢性胃炎患者,采用pH试纸测定胃液pH值,病理切片结合快速尿素酶试验或^(13)C-尿素呼气试验检测H.pylori感染情况。分析不同因素与慢性胃炎患者胃内pH值的相关性。结果:67例患者中,慢性非萎缩性胃炎患者35例(52.2%),慢性萎缩性胃炎32例(47.8%);H.pylori阳性21例(31.3%),H.pylori阴性46例(68.7%)。平均胃内pH值为2.86,胃内pH值随年龄增长呈升高的趋势(P=0.15)。Logistic回归分析显示胃内pH值与性别(P=0.17)、年龄(P=0.06)、糖尿病(P=0.75)、萎缩(P=0.67)和H.pylori感染(P=0.11)均无相关性。结论:性别、年龄、糖尿病、萎缩和H.pylori感染不是影响慢性胃炎患者胃内pH值的重要因素。

Background： It is believed conventionally that gastric acid secretion would decrease following aging and gastric atrophy. But different views are held by other studies. Aims： To investigate the correlation between gastric pH value and gender, age, diabetes, gastric atrophy and Helicobacter pylori （H. pylori） infection. Methods： Sixty-seven chronic gastritis patients were enrolled in this study. Gastric pH value was measured by pH testing paper, H. pylori infection was detected by pathological section combined with rapid urease test or ^13C-urea breath test. The correlation between gastric pH value of chronic gastritis patients and different factors was investigated. Results： Of the 67 patients, 35 （52.2%） patients had chronic non-atrophic gastritis and 32 （47.8%） chronic atrophic gastritis; 21 （31.3%） patients were H. pylori-positive and 46 （68.7%） H. pylori-negative. The average gastric pH value was 2.86. Gastric pH value tended to increase with aging （P= 0.15）, but was independent of gender （P=0.17）, age （P=0.06）, diabetes （P=0.75）, gastric atrophy （P=0.67） and H. pylori infection （P=0.11） by Logistic regression models. Conclusions： Gastric pH value of chronic gastritis patient is independent of gender, age, diabetes, gastric atrophy and H. pylori infection.