摘要
目的:探讨基质金属蛋白酶9(MMP-9)和嗜酸粒细胞(EOS)在鼻息肉组织的表达及其对预后的影响。方法:分别应用免疫组织化学和苏木精-伊红染色的方法,研究预后好(愈合组)和预后差(复发组)的鼻息肉组织中MMP-9和EOS的表达。结果:复发组鼻息肉组织中MMP-9的表达显著高于愈合组,且MMP-9在以EOS为主的鼻息肉中的表达显著增高;愈合组鼻息肉患者以EOS为主的占16.67%,显著低于复发组的62.50%。结论:MMP-9在复发组及EOS组鼻息肉的高表达,提示MMP-9可能通过增加EOS在鼻黏膜局部的浸润,影响了鼻息肉的预后。MMP-9可能作为鼻息肉复发的危险因子之一。
Objective:To study the expression of MMP-9 and eosinophils in nasal polyps and its influence on the prognosis. Method: Study the expression of MMP 9 and EOS on the tissue of nasal polyps of patients who were cured or recurrent and normal nasal mueosa(NM) by immunohistochemistv and HE staining. Result: In the patients of recurrent group(Group B) , the expression of MMP-9 was much stronger than that of good prognosis group (Group A) and NM. The MMP-9 was stronger in the eosinophil nasal polyps than that of non-eosinophil groups. The percentage of EOS in Group A was 16.67%, while 62.50% in the Group B. Conclusion:The stronger expression of MMP-9 on Group B and eosinophil group indicated that MMP-9 might affect the prognosis of nasal polyps through inducing the number of EOS in the mucosa. MMP-9 may be one of the risk factors for the relapse of nasal polyps.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2009年第18期840-842,845,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery