三种头孢类药物的输液稳定性影响因素研究

Study on the influence factors on the stability of cefuroxime,ceftriaxone and cefotaxime injections

目的:研究头孢呋辛钠、头孢曲松钠、头孢噻肟钠在0.9%氯化钠注射液和5%葡萄糖注射液中的稳定性影响因素。方法:在不同的温度(8、25、37℃)、不同光照(光照强度2500 lx、避光)及不同时间(0、0.5、1、2、3 h)条件下测定三种头孢类药物输液中药物的含量、pH值和不溶性微粒等。结果:在不同温度和光照条件下,三种药物与两种输液配伍后3 h内含量基本稳定,头孢呋辛钠和头孢曲松钠在输液中的有关物质随着放置时间延长明显增加,头孢噻肟钠相对不明显。结论:三种头孢类药物与0.9%氯化钠和5%葡萄糖配伍在3 h以内可以任意选择静滴时间,但最好即配即用,其中头孢呋辛钠和头孢曲松钠最好避光滴注;熟悉药物在输液中的稳定性影响因素有利于提高药物的临床疗效,促进合理用药。

AIM： To study the influence factors on the stability of cefuroxime sodium, ceftriaxone sodium and cefotaxime sodiumin mingled in 0.9% sodium chloride injection and 5% glucose infusion. METHODS： In the condition of different temperatures （8, 25 and 37 ℃）, different intensities of illumination （illumination intensity 2500 lx, away from light） and different times （0, 0.5, 1, 2 and 3 h）, the contents, pH and insoluble particles of three kinds of injections were detected. RESULTS： In different temperatures and illumination intensity conditions, the contents of three drugs mingled with the two infusions were in a stable state in 3h. With the extension of storage time, the related substances of eefuroxime sodium and ceftriaxone sodium were increased significantly in the transfusions. Yet the cefotaxime sodium was not increased relatively. CONCLUSION： The three drugs mingled with the two transfusions should be used in 3 h, but it is better to use immediately, and cefuroxime sodium and ceftriaxone sodium should be kept away from light. It is useful for increasing the therapeutic effect and promoting the rational use of drugs to know the influence factors on the stability.