摘要
目的:研究五酯胶囊(Wuzhi-capsule,WZ)与他克莫司(Tacrolimus,Tac)联合应用对肾移植受者Tac血浓度的影响。方法:45名服用Tac+WZ患者为试验组,45名单服Tac患者为对照组,以Tac全血浓度及肝、肾功能生化检测指标作为临床评价指标。结果:合用WZ患者Tac全血浓度与合用前比较明显增加(P<0.01),与对照组比较亦有显著性提高(P<0.01)。WZ与Tac合用对肝、肾功能无明显影响。结论:WZ能明显升高肾移植受者Tac血浓度。在升高Tac血浓度的同时,WZ并不增加Tac的肝肾毒性反应。WZ与Tac合用可减少Tac用药量,节省Tac费用。
AIM: To study the effects of Wuzhicapsule (WZ) on the blood concentrations of Tacrolimus (Tac) in renal transplant recipients. METHODS: The renal transplant recipients were divided into experimental group (45 cases) which treated with Tac plus WZ and control group (45 cases) which were received Tac alone. The blood concentrations of Tac and biochemical values of hepatic and renal functions were determined. RESULTS: The blood concentrations of Tac were significantly higher in experimental group than those in experimental group before combined with WZ( P 〈 0.01) or in control group ( P 〈 0.01 ). Thebiochemical values of hepatic and renal functions between experimental group and control group were no significant difference. CONCLUSION: The WZ can markedly elevate the blood concentrations of Tac in renal transplant recipients and does not increase the liver and kidney toxicity of Tac at the same time. The treatment of WZ combined with Tac can reduce the dosages and costs of Tac in renal transplant recipients.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2009年第7期804-807,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
湖北省卫生厅科研基金资助(2007JX3B38)
关键词
肾移植
他克莫司
血药浓度
五酯胶囊
renal transplantation
tacrolimus
blood concentration
Wuzhi-capsule