摘要
The topography of material surface has important influence on cell behavior and physiological functions. Groove-like pattern has drawn much attention among various patterns, due to the phenomenon of "contact guidance" induced by this kind of topography. This review mainly focuses on "contact guidance" formation as well as its influence on cell behavior and physiological effects. The possible mechanisms of "contact guidance" formation were discussed. The research trend and the potential applications were also suggested.
The topography of material surface has important influence on cell behavior and physiological functions. Groove-like pattern has drawn much attention among various patterns, due to the phenomenon of ＂contact guidance＂ induced by this kind of topography. This review mainly focuses on ＂contact guidance＂ formation as well as its influence on cell behavior and physiological effects. The possible mechanisms of ＂contact guidance＂ formation were discussed. The research trend and the potential applications were also suggested.
作者
ZHOU Feng 1,2, YUAN Lin 1,3, HUANG He 1,2 & CHEN Hong1,2 1 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan 430070, China
2 School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China
3 Biomedical Materials Research Center, Wuhan University of Technology, Wuhan 430070, China
基金
Supported by the National Natural Science Foundation of China (Grant Nos.90606013 and 20634030)
Key Grant Project of Chinese Ministry of Education (Grant No.107080)
