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间充质干细胞治疗急性肺损伤的研究进展

Progress in the treatment of acute lung injury with mesenchymal stem cells
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摘要 间充质干细胞是一种多能造血干细胞。在急性肺损伤中,它可以分化为Ⅰ和Ⅱ型上皮细胞,修复受损的局部组织。此外,间充质干细胞还通过减少促炎症细胞因子IL-1、MIP-2、INF-γ和TNF-α的释放,上调抗炎症细胞因子IL-10、IL-1ra和IL-13的分泌,减轻炎症细胞反应,从而发挥治疗作用。 Mesenchymal stem cell is a kind of multipotent hematopoietic stem cell. In the case of acute lung injury, it can differentiate into Type Ⅰ and Type Ⅱ epithelial cell, and to repair impaired tissues. In addition, mesenchymal stem cells have benefit effects in the treatment of lung injury by reducing proinflammatory factors IL-Ⅰ, MIP-2, INF- γ, TNF-α, increasing antiinflammatory factors IL-10, IL-1ra, IL-13 and alleviating inflammatory response to the acute lung injury.
作者 郑丽坤 张磊 陈乃耀 吴寿岭 赵辉
机构地区 华北煤炭医学院 华北煤炭医学院附属开滦医院骨科 华北煤炭医学院附属开滦医院血液科 华北煤炭医学院附属开滦医院心内科 天津大学化工学院生物制药实验室
出处 《基础医学与临床》 CSCD 北大核心 2009年第9期1002-1006,共5页 Basic and Clinical Medicine
关键词 急性肺损伤 间充质干细胞 acute lung injury mesenchymal stem cells
分类号 R563.8 [医药卫生—呼吸系统]
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参考文献30

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基础医学与临床
2009年 第9期

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