逐瘀安脑丸对模型大鼠脑出血的保护作用研究

Cerebral Protection by Zhuyu Annao Pill against Cerebral Hemorrhage in Model Rats

目的:研究逐瘀安脑丸对模型大鼠脑出血的保护作用。方法:实验分为6组,即空白、模型、安宫牛黄丸及逐瘀安脑丸高、中、低剂量组。以大鼠自体血凝块复制脑血肿模型,用积分法记录神经功能缺损的变化,用干湿比重法测定脑组织水分,同时观察血液流变学、凝血四项与脑组织形态学的变化。结果:与模型组比较,逐瘀安脑丸高、中、低剂量组脑含水量与神经功能缺损积分无显著变化;凝血四项中的凝血酶原时间(PT)显著延长(P<0.05),血液流变学中全血还原黏度显著降低(P<0.05)、红细胞压积显著降低(P<0.05);凝血时间无显著变化;脑组织形态学显著改善。结论:逐瘀安脑丸对急性脑出血有积极的保护作用。

OBJECTIVE： To observe the protective effect of Zhuyu annao pill on model rats against cerebral hemorrhage. METHODS： The experimental rats were randomized to 6 groups： blank group, model group, Angong liuhuang pill group, Zhuyu annao pill high,medium and low dosage groups. Cephalophyma model of rats were duplicated with rats＇ autoblood dot; the neurologic impairment change was recorded by integration method; the water content of the brain tissue was measured by drywet specific density method; meanwhile, the changes in hemorheology, blood coagulation （4 parameters）, the blood co- agulation time and the histology of the morphology of brain tissue were observed. RESULTS： In rats treated with Zhuyu annao pill （high, medium or low dosage） as compared with model group, no significant change was noted in the water content and neurological impairment; however, the protime （PT） was significantly prolonged（P 〈 0.05）, whole blood reduced viscosity reduced significantly（P 〈 0.05）, the hematocrit decreased significantly （P 〈 0.05） but the change in clotting time was not significant.The morphology of model rats＇, brain tissue was improved.CONCLUSION： Zhuyu annao pill poses active protection against acute cerebral hemorrhage and its clinical use is of great potential.