环境空气污染对交通警察血清氧化应激指标的影响

Effect of Air Pollution on Serum Oxidative Stress Indices in Traffic Policemen

目的研究环境空气污染对交通警察血清氧化应激指标超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)和丙二醛(MDA)含量的影响。方法于2007年6—8月进行调查,选取62名北京某城区交通警察作为暴露组,35名远郊社区居民作为对照组,通过统一的问卷调查了解研究对象的一般状况,通过对PM2.5、多环芳烃(PAHs)、NO2等污染物连续2d的环境浓度监测获得研究人群污染物暴露水平,以试剂盒法测定血清SOD、GSH-Px活力及MDA含量。结果暴露组空气NO2、甲醛、苯、甲苯浓度显著高于对照组(P<0.05),暴露组PM2.5、PAHs浓度值高于对照组,但受到样本量的限制,两组间浓度差别没有统计学意义;暴露组的SOD、GSH-Px的活力低于对照组,差别有统计学意义(P<0.05),MDA浓度高于对照组,但差别没有统计学意义(P>0.05);采用多元Logistic模型调整年龄、吸烟、饮酒等因素的影响后,血清SOD、GSH-Px活力仍与空气污染存在显著相关性(P<0.01)。结论空气污染可以导致交通警察血清SOD和GSH-Px活力下降,造成机体氧化应激。

Objective To explore the effect of air pollution on oxidative stress indices （SOD, GSH-Px, MDA） in serum of traffic policemen. Methods From Jun to Aug, 2007, sixty-two traffic policemen and thirty-five male suburban inhabitants were selected. The ambient concentrations of PM2.5, polycyclic aromatic hydrocarbons （PAHs）, nitrogen dioxide, formaldehyde, benzene and toluene were monitored within two consecutive days in the work places of traffic policemen and in the residential areas of suburban inhabitants to assess their air pollution exposure levels. The activity of SOD, GSH-Px and the concentration of MDA in serum were determined with regent kits, while the information on smoking, drinking alcohol, exercising habit and so on was investigated by questionnaire. Results There were significant differences in the concentrations of nitrogen dioxide, formaldehyde, benzene and toluene between the two study groups. The average levels of PM2.5 and PAHs in the traffic policeman group were also higher than those in the control group, but this difference was not significant for small sample size. The activities of SOD and GSH-Px in the traffic policeman group were significantly higher than those in the control group, while the difference of MDA concentration between the two groups was not significant. The relationship between air pollution and the activity of SOD and GSH-Px were also significant after controlling the influence of other factors. Conclusion Air pollution can decrease the activity of SOD and GSH-Px in serum of traffic policemen and induce oxidative stress.