大气颗粒物对心血管系统疾病的影响及其机制的研究进展

Impact and Mechanism of Ambient Particulate Matter on Cardiovascular Diseases

国内外多项流行病学调查及实验研究表明,大气PM10、PM2.5暴露与心血管疾病的入院率和死亡率有关。目前认为大气颗粒物主要通过造成血管功能障碍、促进动脉粥样硬化形成、引起心律失常及氧化应激和炎性反应对心血管系统健康产生损害。其中对沙尘颗粒物与心血管系统疾病关系的研究尚不多且结论并不一致。笔者对近年来国内外关于大气颗粒物与心血管系统疾病的关系及作用机制的研究进展做简要综述。

A series of epidemiological and experimental studies demonstrate a positive and significant association between exposure to particulate matter and cardiovascular-related incidence and hospitalization. Several possible mechanisms have been proposed, including vascular dysfunction, atherogenesis, arrhythmogenesis and oxidative stress and inflammation. So far the studies on the effect of particulate matter derived from dust events on cardiovascular diseases are limited, and different conclusions are drawn. The advances in recent studies were reviewed in this paper, and suggestions for further research were made.