甲醛的雄性生殖毒性研究进展

Advances in Research on Adverse Effect of Formaldehyde on Male Reproductive System

甲醛(formaldehyde)在医学上常被用作消毒剂和防腐剂,近年来作为粘合剂原料广泛用于室内装修。已有动物实验显示,甲醛对雄性生殖内分泌功能、精子数量和质量均有不良影响,但人群研究尚少。损伤遗传物质、诱导脂质过氧化和细胞凋亡是其可能毒作用机制。该文综述了甲醛的雄性生殖毒性研究现状和可能作用机制。

Formaldehyde is a chemical which is traditionally used as disinfectant and preservative. Recently, formaldehyde becomes raw material of adhesive which is widely used for indoor decoration. It has been recently reported in many animal experiments that formaldehyde had adverse effects on male reproductive endocrine, sperm quantity and quality, and but few reports were obtained about the adverse effects of formaldehyde on male reproductive system in human beings. Damage to genetic material, induced by lipid peroxidation and cell apoptosis is the possible mechanism of toxic effect. Male reproductive toxicity and mechanism of formaldehyde were discussed, and the recent researches were reviewed in the present paper.