钙蛋白酶系统基因的研究进展

Research Progress of Calpain System Gene

钙蛋白酶系统主要由钙蛋白酶(calpainⅠ,CAPN1和calpainⅡ,CAPN2),钙蛋白酶抑制蛋白(calpastatin,CAST)及骨骼肌特异性钙蛋白酶(muscle specific calpain,p94,CAPN3)组成。钙蛋白酶是细胞质中主要的蛋白水解酶,在肌原纤维蛋白降解中起着重要的作用。肌肉增长和宰后嫩度的变化与蛋白质水解程度密切相关。因此,钙蛋白酶的活性会影响畜禽肌肉增长和肉的嫩度。对钙蛋白酶系统基因的结构、活性调节、作用机理及其对肉质的影响进行了综述,并讨论其应用前景。

Clpain system consists of calpain Ⅰ（CAPN1 ） ,calpain Ⅱ（CAPN2） ,calpastatin （CAST） and muscle specific calpain,CAPN3. Calpoin system is probably the major proteolytic enzyme in protein degradation,which plays an important role in myofibrillar protein degradation. The muscle growth and postmortem tenderization of meat are highly related to the degree of proteolysis,so the activity of calpain system has an effect on muscle growth and meat tenderness. The article reviewed the structure, activity regulation, function mechanism, effects on meat quality and discussed the application prospect of calpain system.