期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

巨噬细胞移动抑制因子在动脉粥样硬化中的研究进展 被引量：3

Progression of macrophage migration inhibitory factor in atherosclerosis
下载PDF
导出
摘要 巨噬细胞移动抑制因子(MIF)是一种高度保守的的多能细胞因子,受下丘脑-垂体控制,在调节机体固有免疫和获得性免疫中发挥重要作用。MIF在机体中分布广泛,并参与了多种疾病的发生和发展过程。近年来MIF在动脉粥样硬化中的作用倍受关注,研究证实MIF参与了动脉粥样硬化的发生、发展及演化过程。虽然大多数研究承认MIF与冠状动脉性心脏病之间存在相关性,但仍存在许多争议,其与冠状动脉性心脏病的相关性研究目前仍处于起步阶段。 Macrophage migration inhibitory factor （MIF） is a highly conservative and multipotent cytokines, which is widely distributed in the body and play an important role in the regulation of innate immunity and acquired immunity under the control of the hypothalamus-pituitary. MIF may be involved in a variety of physiological and pathological responses. Recent years, the role of MIF played in atherosclerosis was paid more attention to. Researches showed that MIF participated in the development and evolution of atheroselerosis. Although most of the researches admit the correlation between MIF and coronary heart disease, but there are still a lot of controversy, and its relationship with coronary heart disease is still in its infancy.
作者 张韶辉 高东升
机构地区 天津医科大学 济宁医学院附属医院心内科
出处 《国际内科学杂志》 CAS 2009年第9期524-527,共4页 International Journal of Internal Medicine
关键词 巨噬细胞移动抑制因子 动脉粥样硬化 冠状动脉性心脏病 Macrophage migration inhibitory factor Atherosclerosis Coronary heart disease
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献19

  • 1Bloom BR, Bennett B. Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science, 1966, 153(731 ) :80-82.
  • 2David JR. Delayed hypersensitivity in vitro:its mediation by cell-free substances formed by lymphoid cell-antigen interaction. Proc Natl Acad Sci U S A,1966,56(1) :72-77.
  • 3Calandra T, Roger T. Macrophage migration inhibitory factor: a regulator of innate immunity. Nat Rev Immunol, 2003,13 (10) :791-800.
  • 4Flaster H, Bernhagen J, Calandra T, et al. The macrophage migration inhibitory factor-glucocorticoid dyad:regulation of inflammation and immunity. Mol Endocrinol, 2007,21 ( 6 ) : 1267-1280.
  • 5Donn RP, Ray DW. Macrophage migration inhibitory factor: molecular, cellular and genetic aspects of a key neuroendocrine molecule. Endocrinology, 2004,182 ( 1 ) : 1-9.
  • 6Sato A, Uinukool TS, Kuroda N, et al. Macrophage migration inhibitory factor (MIF) of jawed and jawless fishes :implications for its evolutionary origin. Dev Comp Immunol, 2003,27(5) :401-412.
  • 7Schober A, Bernhagen J, Thiele M, et al. Stabilization of atheroselerotic plaques by blockade of macrophage migration inhibitory factor after vascular injury in apolipoprotein E-deficient mice. Circulation,2004,109 ( 3 ) : 380-385.
  • 8Burger-Kentischer A, Goebel H, Seiler R, et al. Expression of macrophage migration inhibitory factor in different stages of human atherosclerosis. Circulation, 2002,105 ( 13 ) : 1561-1566.
  • 9Pan JH, Sukhova GK, Yang JT, et al. Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprote- in receptor-deficient mice. Circulation, 2004,109(25) :3149-3153.
  • 10林秋雄,刘晓颖,杨敏,符永恒,单志新,余细勇,黄小穗,郑猛,林曙光.实验性动脉粥样硬化家兔MIF、TNF-α和IL-6水平的研究[J].现代生物医学进展,2007,7(6):843-845. 被引量：15

二级参考文献36

  • 1[1]David JR. Delayed hypersensitivity in vitro: its mediation by cell free substances formed by lymphoid cell-antigen interaction. Proc Natl Acad Sci USA, 1966, 56:72 ～ 77
  • 2[2]Bloom BR, Bennett B. Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science, 1966,153:80～82
  • 3[3]Bernhagen J, Calandra T, Bucala R. Regulation of the immune response by macrophage migration inhibitory factor:biological and structural features. J Mol Med, 1998, 76:151～161
  • 4[4]Bernhagen J, Calandra T, Mitchell RA, et al. MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia.Nature, 1993, 365:756～759
  • 5[5]Calandra T, Bemhagen J, Metz CN, et al. MIF as a glucocorticoid induced modulator of cytokine production. Nature,1995, 376:68～71
  • 6[6]Bozza M, Satoskar AR, Lin G, et al. Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis. J Exp Med, 1999, 189:341～346
  • 7[7]Shu-Guang Lin, Xi-Yong Yu, Yong-Xiong Chen, et al. De novo expression of macrophage migration inhibitory factor in atherogensis in rabbits. Circulation Research, 2000, 87:1202～1208
  • 8[8]Cheuk-Man Yu, Chu-Pak Lau, Kevin Wing-hon, et al. Elevation of plasma level of macrophage migration inhibitory factor in patients with acute myocardial infarction. The Ameri J of Cardiol, 2001, 88:774～777
  • 9Kong YZ, Huang XR, Ouyang X, et al. Evidence for vascular macrophage migration inhibitory factor in destabilization of human atherosclerotic plaques. Cardiovasc Res, 2005,65: 272-282.
  • 10Kong YZ, YU X, Tang JJ, et al. Macrophage migration inhibitory factor induces MMP-9 expression: implications for destabilization of human atherosclerotic plaques. Atherosclerosis, 2005,178: 207-215.

共引文献41

同被引文献29

  • 1林秋雄,余细勇,单志新,林曙光,Huiyao Lan.氧化型低密度脂蛋白诱导巨噬细胞移动抑制因子的表达[J].中国病理生理杂志,2004,20(10):1794-1797. 被引量：13
  • 2Ross R.Atherosclerosis -an inflammatory disease[J].N Engl J Med,1999,340(2):115-26.
  • 3Chiu JJ,Usami S,Chien S.Vascular endothelial responses to altered shear stress:pathologic implications for atherosclerosis[J].Ann Med,2009,41(1):19-28.
  • 4Wong WT,Ng CH,Tsang SY,et al.Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium -dependent relaxation in rat aorta[J].Nutr Metab Cardiovase Dis,2009,21(3):158-64.
  • 5Matsumoto Y,Adams V,Walther C,et al.Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis:a novel concept for valvular endothelial cell repair[J].Eur Heart J,2009,30(3):346-55.
  • 6Ishikado A,Nishio Y,Yamane K,et al.Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells[J].Atherosclerosis,2009,205(2):404-12.
  • 7Chen L,Yang G,Zhang X,et al.Induction of MIF expression by oxidized LDL via activation of NF-kappa B in vascular smooth muscle cells[J].Atherosclerosis,2009,207(2):428-33.
  • 8Seizer P,Schonberger T,Schott M,et al.EMMPRIN and its ligand cyclophilin A regulateMT1-MMP,MMP-9 and MCSF during foam cell formation[J].Atherosclerosis,2010,209(1):51-7.
  • 9Kim HR,Lee DM,Lee SH,et al.Chlorogenic acid suppresses pulmonary eosinophilia,IgE production,and Th2-type cytokine production in an ovalbumin-induced allergic asthma:activation of STAT-6 and JNK is inhibited by chlorogenic acid[J].Int Immunopharmacol,2010,10(10):1242-8.
  • 10Cheng Y,Zhang J,Hou W,et al.Immunoregulatory effects of sinomenine on the T-bet/GATA-3 ratio and Th1/Th2 cytokine balance in the treatment of mesangial proliferative nephritis[J].Int Immunopharmacol,2009,9(7-8):894-9.

引证文献3

二级引证文献20

国际内科学杂志
2009年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部