内质网应激与酒精性肝病

Endoplasmic reticulum stress and alcoholic liver disease

在酒精性肝病的发病机制中,内质网应激作为新的关注点已经进入人们的视野。内质网应激是内质网内未折叠或错误折叠蛋白积聚所致,适宜的应激有利于细胞内环境的恢复,然而严重而持久的内质网应激将导致细胞凋亡。肝细胞具有高度发达的内质网,是对内质网应激最敏感的细胞之一,目前的研究也表明在细胞和动物模型中,内质网应激参与了酒精性肝病的发病过程。本文就内质网应激在酒精性肝病中的作用作一综述。

Endoplasmic reticulum stress as a new concern during the pathogenesis of alcoholic liver disease （ALD） has entered the people＇s vision. Endoplasmic reticulum stress caused by the accumulation of misfolded and unfolded proteins in the endoplasmic reticulum. Appropriate stress was benefical to recovery of intracellular environment, however, serious and persistent stress may lead to apoptosis. Hepatocytes are one of the most sensitive ceils, which contain abundant endoplasmic reticulum. Existing study has indicated that endoplasmic reticulum contributed to the development of ALD in cell and animal models. In this review, we summaried the role of endoplasmic stress in the pathogenesis of ALD.