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慢性脑缺血导致认知障碍的病理生理学机制 被引量：5

Pathophysiological mechanisms of cognitive impairment caused by chronic cerebral hypoperfusion
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摘要 慢性脑缺血是一种常见的病理学状态，早期以认知功能损害为主要表现，最终导致持久或进展性认知障碍和神经功能缺损。慢性脑缺血引起的神经元损伤、突触异常、能量障碍以及中枢胆碱能和单胺能系统功能缺损是其导致认知障碍的病理生理学机制。 Chronic cerebral hypoperfusion is a common pathological state. Cognitive impairment is its main manifestation in early stage, and it will eventually result in persistent or progressive cognitive impairment and neurological deficits. Chronic cerebral hypoperfusion caused neuronal damage, synapse abnormity, energy impairment and the function defects of central cholinergic system and monoaminergic system are its pathophysiological mechanisms resulting in cognitive impairment.
作者 肖俊杰 成燕 詹青
机构地区 同济大学附属同济医院内科
出处 《国际脑血管病杂志》 北大核心 2009年第8期614-617,共4页 International Journal of Cerebrovascular Diseases
基金 上海市卫生局青年基金（20083（051）
关键词 脑缺血 认知障碍 cerebral ischemia cognition disorders
分类号 R749.1 [医药卫生—神经病学与精神病学]
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参考文献18

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共引文献9

同被引文献38

  • 1曹晶晶,程友琴.老年抑郁症与心血管疾病的关系[J].中华老年心脑血管病杂志,2005,7(3):206-207. 被引量：42
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引证文献5

二级引证文献21

国际脑血管病杂志
2009年 第8期

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