Rho激酶与缺血性脑血管病

Rho kinase and ischemic cerebrovascular disease

缺血性脑血管病可导致严重的神经功能缺损，甚至死亡。Rho激酶是Rho蛋白的重要下游底物，参与血管平滑肌收缩、细胞迁移、炎症细胞浸润以及血管内皮功能障碍等多种生物学效应，在缺血性脑血管病的发生、发展和梗死体积扩大等过程中起着重要作用。Rho激酶抑制剂可有效舒张痉挛血管，减轻局部炎症反应，保护内皮功能，增加缺血区域血流，缩小梗死体积，改善神经功能。

Ischemic cerebrovascular disease may result in severe neurological deficits, and even death. Rho kinase is an important downstream substrate of Rho protein. It involves in multiple biological effects, including vascular smooth muscle Contraction, cell migration, inflammatory cell infiltration and vascular endothelial dysfunction. It plays important roles in the processes of the occurrence, development and expansion of infarct volume in ischemic cerebrovascular disease. Rho kinase inhibitor can effectively relax vascular spasm, reduce local inflammatory response, protect endothelial function, increase blood flow in ischemic region, reduce infarct volume, and improve neurological function.