非上皮性肿瘤组织中CD117、CD34的表达

Expressions of CD117 and CD34 in non-epithelial tumours

目的:探讨胃肠道间质瘤的诊断和免疫组化结果。方法:收集我院1995～2005年手术切除的胃肠道非上皮性肿瘤存档的36份病例进行研究。结果:典型的平滑肌和神经来源的肿瘤CD117和CD34阴性,间质瘤是Desmin和Actin阳性反应以外CD117、CD34均为阳性表达,神经来源的肿瘤NSE和S-100均阳性表达。结论:间质瘤(GIST)是消化道最常见的间叶源性肿瘤,间质瘤的生物学特点与胃肠平滑肌瘤和神经鞘瘤不同,免疫组化常表达CD117、CD34。

Objective： To discuss the gastrointestinal stromal diagnosis and the results of immunohistochemistry. Methods： Thirty six cases of archival which were the surgical resection of gastrointestinal non-epithelial tumors in 1995-2005 in our Hospital were researched. Results： In the typical smooth muscle and nerve tumor, CDl17 and CD34 were negative. Positive expressions of CD117 and CD34, were found is gastrointestinal stromal tumours as well as the expression of Desmin and Actin. The neural tumor could be expressed with NSE and S 100. Conclusion： Gastrointestinal stromal tumour is the mos, common gastrointestinal mesenchymal tumors. The gastrointestinal stromal tumour of biological characteristics is different from intestinal smooth muscle tumours and nerve sheath tumours. The result of immunohistochemical was expressed of CD117 and CD34.