乌鲁木齐市健康体检人群非酒精性脂肪性肝病患病状况调查

Epidemiological survey of prevalence of nonalcoholic fatty liver disease in examination receivers of Urumqi

目的:调查乌鲁木齐市体检人群非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)患病率及其相关生化指标。方法:调查2008年1月至2008年12月期间在新疆医科大学第一附属医院体检者1916例,内容包括一般资料、血生化检查以及肝脏实时超声检查。结果:1916例体检者完成调查,共检出脂肪肝467例,其中非酒精性脂肪肝446例,患病率为23.26%。男性患病率为35.72%,女性患病率为9.9%。男性NAFLD患病率在50岁之前随年龄增长而增加,50岁之后开始下降,女性在70岁之前NAFLD患病率随年龄增长而增加,除60～70岁年龄组男女两性患病率无差异(P>0.05)外,其他各组均显著高于女性(P<0.01);各年龄组NAFLD患病率民族差异无显著性(P均>0.05),随年龄增加两民族患病率均呈上升趋势,但两民族患病率的高峰有所不同,汉族以30～40组患病率最高,达26.43%,维吾尔族以40～50组患病率最高,达31.71%。NAFLD组甘油三酯(TG)、低密度脂蛋白-胆固醇(LDL-C)、丙氨酸氨基转氨酶(ALT)、谷氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(GGT)、尿酸(UA)等均显著高于对照组,高密度脂蛋白胆固醇(HDL-C)水平显著低于对照组(P均<0.05);空腹血糖(GLU)、总胆固醇(TC)在两组中差异无显著性(P>0.05)。结论:乌鲁木齐市健康体检人群非酒精性脂肪肝患病率高,血脂异常及其相关的多元代谢紊乱与非酒精性脂肪性肝病的关系密切,性别、年龄和民族可能是NAFLD的间接因素,ALT、AST、GGT等肝脏酶学指标测定可作为非酒精性脂肪性肝病的预测指标。

Objective： To investigate the prevalence of nonalcoholic fatty liver disease （NAFLD） and correlated biochemical indexes among examination receivers in Urumqi. Methods： 1 916 participants were investigated in the First Affiliated Hospital of Xinjiang Medical University during June,2007 to December, 2008. General investigation, serum biochemical examination and uhrasonographic examination of liver were under taken. Results： A total of 1 916 receivers took part in the survey. Of the 1 916, 467 Fatty liver was detected, among which 446 had nonalcoholic fatty liver. The prevalence of NAFLD in examination receivers in Urumqi was 23.26 %. It was 35.72% in males and 9.9% in females . The prevalence of NAFLD was increased with aging in males younger than 50 years old and in females younger than 70 years old. The prevalence of NAFLD in males was significantly higher than that in females in every aging group except 60-70 group （P〈0.01）. There is no significant difference on the prevalence of NAFLD between the Uygur nationality and the Han nationality （P 〈0.05）, in all groups, but the summit of the prevalence of NAFLD in the Uygur nationality was different from that in the Han nationality. Triglyceride（TG）, low-density lipoprevalence of NAFLD among examination receivers in Urumqi. Metabolic disorders such as obesity and diabetes mellitus, hypertension and hyperlipidemia are closely associated with NAFLD in Urumqi. Sex, age and nationality were probably the indirect factors of NAFLD. The serum GGT level can be treated as a predict index of NAFLD.