摘要
综述黄酮类化合物诱导肿瘤细胞凋亡的机制及其实验研究进展。黄酮类化合物广泛存在于植物中,具有多种生物学活性,其诱导肿瘤凋亡的过程涉及激活和上调Caspase-3、调节Bax/Bcl-2表达水平和胞内钙离子浓度、降低线粒体膜电位、促进细胞色素C释放等,并与p53、ERK、NF-κB等多种调节因子相关。
The recent researches on mechanism of flavonoids-induced apoptosis in cancer cells were reviewed. Flavonoids, a class of natural polyphenol compounds, show multiple bioactivities. Activating and up-regulating Caspase-3, modulating Bax/Bcl-2 expression level and intracellular Ca^2＋ level, decreasing the mitochondrial transmembrane potential and promoting the release of cytochrome C are involved in the induction of apoptosis in cancer cells by the compounds, which is associaled with the such as p53, EPK, NK-κB and so on. regulatory factors,
出处
《药学进展》
CAS
2009年第9期402-408,共7页
Progress in Pharmaceutical Sciences
基金
国家自然科学基金资助项目(30701032)
国家高技术研究发展计划(863计划)资助项目(2003AA2Z3267)
关键词
黄酮类化合物
肿瘤
凋亡
作用机制
实验研究
flavonoids
tumor
apoptosis
mechanism of action
experimental research
