急性脑梗死患者血清尿酸水平的变化与纤维蛋白原的关系探讨

Altered Serum Uric Acid and Its Correlation with Fibrinogen in Acute Brain Infaction

目的了解血尿酸水平及纤维蛋白原(Fg)水平在急性脑梗死患者中的变化及二者的相关性。方法回顾性分析130例脑梗死患者和60例健康体检者血尿酸水平和纤维蛋白原的变化。结果脑梗死组与对照组高尿酸血症检出率、Fg增高检出率间差异均有统计学意义(P<0.05)。脑梗死患者中高尿酸血症者Fg为(4.87±1.56)g/L,非高尿酸血症者Fg为(4.26±1.32)g/L,两组患者Fg水平间差异有统计学意义(P<0.05)。结论血尿酸水平与急性脑梗死的发生有一定相关性,可能与增加纤维蛋白原含量,促进血栓形成有关。

Objective To investigate the relationship between uric acid （UA） and fibrinogen （Fg） in acute brain infarction. Methods To analyze the level of serum UA and the content of Fg in 130 cases of brain infarction and 60 cases of healthy individuals retrospectively. Results Both the concentration of serum UA and content of Fg in the brain infarction group were higher than those in the control group （P 〈 0. 05）. Concentration of Fg in the brain infarction group with high level of UA was higher that with normal or low level of UA. Conclusion There was a certain correlation between serum UA and acute brain infarction. The possible mechanism is that serum UA may increase the content of Fg, and so promote the formation of thrombus.