摘要
五味子乙素200或400mg/kg 腹腔注射,能显著提高腹腔巨噬细胞的吞噬功能和血清溶血素的含量,对腹水型肝癌细胞 DNA 合成的半抑制剂量为81μg、mL.其抑制机理为干扰了 DNA 的代谢,而不损伤 DNA 的模板.五味子乙素200mg/kg 连续或隔日腹腔注射.能显著提高移植腹水型肝癌小鼠的存活率.
The phagocytosis of macrophage and the content of hemolysin in miceserum significantly increase by the treatment of γ-schisandrin of 200 or400 mg/kg by intraperritoneal injection(ip).The half inhibition dose ofγ-schisandrin on DNA synthesis in ascitic hepatoma cells is 81μg/mL.The inhibition mechanism of DNA synthesis is due to the fact that the DNAmetabolism is disturbed rather than DNA replication template is damaged byγ-schisandrin.Tile survival of mice bearing transplantic ascitic hepatomaincrease obviously by a 200 mg/kg of γ-schisandrin ip continuously each forone day or for two days.
出处
《兰州大学学报（自然科学版）》
CAS
CSCD
北大核心
1990年第1期55-59,共5页
Journal of Lanzhou University(Natural Sciences)
关键词
五味子乙素
肝癌
癌细胞
DNA
合成
phagocytosis
hemolysin
γ-schisandrin
DNA synthesis DNA damage
