老年原发性高血压患者晨峰现象与靶器官损害

Association between morning blood pressure surge and target organ damage in elderly patients with essential hypertension

目的探讨老年原发性高血压晨峰(MBPS)现象对靶器官损害的影响。方法老年原发性高血压患者186例,依24 h动态血压分MBPS组(104例)和非MBPS组(82例)。所有对象进行心脏和颈动脉超声检查,计算左室质量指数(LVMI)、颈动脉内膜中层厚度(IMT)及斑块的发生率。结果MBPS组24 h、白昼以及夜间平均收缩压、脉压均较非MBPS组高(P<0.05或P<0.01),MBPS组的LVMI及左右两侧颈动脉IMT均明显高于非MBPS组(P<0.05或P<0.01);颈动脉斑块的发生率MBPS组显著高于非MBPS组(P<0.01)。结论老年原发性高血压患者具有MBPS现象者有明显的靶器官损害。

Objective To investigate the association between the morning blood pressure surge （MBPS） and the target organ damage in eldealy patients with essential hypertension. Methods One hundred and eighty-six patients were divided into MBPS group （n = 104） and non-MBPS group（ n = 82） according to 24 h ambulatory blood pressure monitoring. Left ventricular mass index （LVMI） ,carotid intima-media thickness （IMT） were determined, and the frequency of carotid atherosclerosis and plaque were compared between two groups. Results 24 h, day and night mean systolic blood pressure, pulse pressure in MBPS group were significantly higher than those in non-MBPS group （ P 〈 0. 05 ）. In MBPS group, LVMI, carotid IMT, carotid atherosclerosis and plaque were higher than those in non-MBPS group（P 〈 0. 01 ）. Conclusions Elderly patients with essential hypertension with MBPS have evident target organ damage.