长托宁治疗急性有机磷中毒的血常规动态观察

Dynamic Observation on Blood Parameters in Patients with Acute Organophorus Pesticides Poisoning Treated with Penehyclidine Hydrochloride

目的:探讨急性有机磷中毒患者(AOPP)血常规动态变化特点及长托宁的干预效果观察。方法:对我院34例急性有机磷中毒患者采用长托宁治疗,分析了入院第1,3,5,7,9天患者血液的各种指标动态变化趋势。结果:长托宁治疗后患者的血液指标均得到明显改善,治疗前后血液指标的差异有统计学意义(P<0.05);不同中毒程度各种血液指标的差异有统计学意义(P<0.05),其中除了白细胞数量(WBC)和中性粒细胞比例(N)在重度中毒患者中最高,而其他血液指标值在重度中毒患者中最低;对患者有无并发症的分析显示:两者之间除了平均红细胞体积(MCV)和血小板比积(PCT)的差异没有统计学意义(P>0.05)其他各种血液指标的差异均有统计学意义(P<0.05)。结论:长托宁对急性有机磷中毒的治疗效果好,不同中毒程度以及患者并发症的有无对血液指标有明显的影响,为急性有机磷中毒的病理变化提供理论基础,有助于临床病情的观察以及预后的判断。

Objective： To study the dynamic changes of blood parameters in patients with acute organophorus pesticides poisoning （AOPP） and clinical interventional effects of Penehyclidine hydrochloride. Methods： 34 patients with acute organophorus pesticides poi- soning were taked the treatment of Penehyclidine hydrochloride, and analyzed on dynamic changes of blood parameters in the first, third, fifth,seventh and ninth day after admission. Results： The blood parameters of patients got the significant improvement after the treatment ofPenehyclidine hydrochloride. There were statistical significance in blood parameters of patients pre and post treatment （P〈0.05）. The results of blood parameters in AOPP patients had statistical significance among different degree poisoning （P〈0.05）. The vaule of WBC and N were highest, and the vaule of other parameters were lowest in severe poisoning group. The results of MCV and PCT had no statis- tical significance （P〉0.05）, and the results of other parameters had statistical significance in AOPP patients with complications and non-complications （P〈0.05）. Conclusions： The AOPP patients can get good clinical effect by the treatment of Penehyclidine hydrochlo- fide. The different degree poisoning and complications will obviously effect on the blood parameters of AOPP patients. It privides the theoretical basis on pathological changes of AOPP patients. It is helpful to observe the clinical severity and to evaluate prognosis of patients.