成份输血对胃癌术后血清IL-6、IL-10、COX-2、PGE_2含量的影响

Effect of component blood transfusion on IL-6,IL-10,COX-2,PGE_2 in serum of patients after subtotal gastrectomy

目的:观察围手术期成份输血对胃癌患者炎症反应的影响。方法:随机选择胃癌病人分为3组:对照组,压积红细胞组,全血组。分别采用ELISA法和放免法检测患者术前及术后低1、3、7、14天血清中IL-6、IL-10、COX-2及PGE2含量。结果:手术后第一周是感染发生的主要时期,两周后,炎症反应基本消失,输血能升高患者血清中的促炎因子,降低抗炎因子IL-10的表达,但相对于输异体全血,输成份血能降低血清中COX-2、PGE2、IL-6的含量,升高血清IL-10的含量。结论:胃癌患者围手术期输血能促进机体的炎症反应,成份输血致炎效果弱于输异体全血。

Objective： To study the effect of component blood transfusion on IL-6,IL-10,COX-2,PGE2 in serumof patients after subtotal gastrectomy. Method：The study consisted of 36 patients with gastric cancer, all patients underwent subtotal gastrectomy. The patients were divided into non-blood transfusion group, whole blood transfusion group and component blood transfusion. The contents of IL-6,IL-10,COX-2,PGE2 in serum were detected before operation, on 1st, 3nd, 7th and 14th day after operation by ELISA and radioim- munity methods, respectively. Results： The contents of IL-6,COX-2,PGE2 in serum in blood transfusion group was higher than that in non-transfusion group, and the contents of IL-l 0 was lower than that in non-transfusion group. The contents of IL-10 in serum in whole blood transfusion group, was higher than that in component blood transfusion group, and the contents of IL-10 was lower than that in component blood transfusion group. Conclusion： Blood transfusion could promote inflammation reaction in gastric cancer patients un- derwent subtotal gastrectomy, correspondence to whole blood transfusion, component blood transfusion could attenuate inflammation reaction in gastric cancer patients underwent subtotal gastrectomy.