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恶性肿瘤骨转移分子机制的研究进展 被引量：13

Advances in molecular biological studies of bone metastases machines
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摘要 骨转移是乳腺癌、前列腺癌等晚期恶性肿瘤的常见并发症。癌细胞增殖转移到骨引起溶骨性和成骨性骨损伤,其发生是多个因素共同作用的结果。近年来的研究发现肿瘤细胞与骨微环境之间存在相互作用,骨基质中富含的某些细胞因子如转化生长因子(TGF-β)、胰岛素样生长因子(IGF-Ⅰ和IGF-Ⅱ)等直接促进肿瘤细胞生长,并在维持骨形成和骨破坏的动态平衡中发挥重要作用。骨微环境中的物理因素包括缺氧、高钙、酸中毒等也为肿瘤生长提供适宜的条件。本文主要从分子水平阐述肿瘤骨转移过程中涉及到的肿瘤细胞与骨微环境之间的相互作用。
作者 初云霞 王秀问
机构地区 山东大学齐鲁医院肿瘤防治中心
出处 《中国肿瘤生物治疗杂志》 CAS CSCD 北大核心 2009年第4期422-426,共5页 Chinese Journal of Cancer Biotherapy
基金 山东省科技厅重点攻关项目(No.2006GG3202010)~~
关键词 肿瘤 骨转移 骨微环境 细胞因子
分类号 R730.2 [医药卫生—肿瘤] R738.1 [医药卫生—肿瘤]
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参考文献28

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二级参考文献21

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中国肿瘤生物治疗杂志
2009年 第4期

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