自动体积测量技术在卵泡监测中的应用研究

Assessment of the ability of the new software SonoAVC to measure follicular volume

目的评价自动体积测量（SonoAVC）技术测量卵泡体积的准确性、可重复性以及时效性。方法分别使用三径体积计算法、虚拟器官计算机辅助分析（VOCAL）法和SonoAVC法测量卵泡的体积，以VOCAL为标准判断其他二种方法的准确性，以最大卵泡体积的观察者间的比较来判断可重复性，以测量所需的时间来判断时效性。结果50名患者共测量了176个卵泡，VOCAL法和SonoAVC法的测量数据有高度相关性，三径体积计算法较差；VOCAL法和SonoAVC法的可重复性较好，三径体积计算法较差；而VOCAL法耗时较多。结论SonoAVC在准确性、可重复性以及效率三方面均具有明显的优势，是卯泡评估的理想工具。

Objective To assess the ability of the new software SonoAVC to measure follicular volume and to compare these volume calculations with those made by conventional methods. Methods Three dimensional ultrasound imaging was used to acquire volumetric data from the ovaries of 50 women undergoing controlled ovarian stimulation as part of in vitro fertilization treatment. SonoAVC was used to automatically measure the volume of follicles and virtual organ computer-aided analysis（VOCAL） was also applied to measure volume, which was used as the standard of volume measurement. And the three perpendicular diameters （xyz diameters） of follicles were manually measured by conventional two dimensional（2D） ultrasound, which were used to estimate volume using the sphere formula. And the validity of each technique was compared using limits of agreement. Results One hundred and seventy-six follicles were studied. SonoAVC and VOCAL provided highly accurate and repeatable follicular volume measurements in all cases. Volumes estimated from manually derived follicular diameter measurements were less accurate and repeatable. VOCAL took more time in follicular volume of measurement than SonoAVC and conventional 2D displays. Conclusions SonoAVC provides highly accurate, repeatable,and efficient measurements of follicular volume.