糖尿病肾病患者抵抗素与胰岛素抵抗的关系及临床意义

Clinical significance and the correlations between serum resistin and insulin resistance in type 2 diabetes patients with nephropathy

目的探讨糖尿病肾病(DN)患者血清抵抗素与胰岛素抵抗(IR)的关系及临床意义。方法检测61例2型糖尿病(T2DM)患者(DN组31例、无DN组30例)及30例健康对照者的血清抵抗素、空腹血糖(FPG)、空腹胰岛素(FIns)及胰岛素抵抗指数(Hom a-IR),分析血清抵抗素水平与各检测指标的相关性。结果与对照组比较,DN组、无DN组的血清抵抗素、FPG、FIns、Hom a-IR均明显升高(P均<0.05);与无DN组比较,DN组上述指标虽有升高趋势,但均无统计学差异(P均>0.05)。相关分析显示,DN组血清抵抗素水平与FPG、FIns、Hom a-IR均呈显著正相关(P<0.05)。结论抵抗素与DN患者的IR密切相关,检测T2DM患者的血清抵抗素变化,在一定程度上可反映其肾脏病变。

Objective To explore the correlations between serum resistin and insulin resistance in type 2 diabetes patients with nephropathy and analyze its clinical significance. Methods To examine the serum resistin, blood glucose and the index of insulin resistance separately in 31 type 2 diabetic patients with nephropathy, 30 type 2 diabetic patients without nephropathy and 30 normal control subjects, and to analyze correlation between serum resistin and every index level. Resuits The serum levels of resistin, FPG, Fins and Homa-IR in type 2 diabetic patients with or without nephropathy were significantly increased as compared with normal controls （ P 〈 0.05 ）. Though there was no significant difference in all the above dates in type 2 diabetic patients with or without nephropathy（ P 〉 0.05 ）, the absolute values in the former were higher than those in the latter. Correlation analysis showed the serum resistin levels in type 2 diabetic patients with nephropathy were positively correlated with the levels of FPG, Fins and Homa-IR（ P 〈 0.05 ）. Conehtsions Resistin is intimately cor- related with the insulin resistance of type 2 diabetic patients with nephropathy. The serum level of resistin can in a certain reflect the destroy degree of diabetic nephropathy.