乳腺癌淋巴结转移与Ki67、VEGF表达的相关性及其临床意义

Correlations between the Lymph Node Status and the Expressions of Ki67,VEGF in the Tissues from Patients with Breast Cancer

目的探讨乳腺癌淋巴结转移与VEGF(血管内皮生长因子)、Ki67表达的相关关系及其临床意义。方法采用免疫组化法检测125例乳腺癌组织中VEGF、Ki67的表达以及淋巴结转移的情况。结果腋窝淋巴结转移阳性率为72.8%,VEGF、Ki67表达阳性率分别为:56.8%和74.4%,VEGF与Ki67表达呈正相关(P<0.01),淋巴结转移与Ki67表达无显著相关(P>0.05),而与VEGF表达呈正相关(P<0.01)。结论VEGF和Ki67在肿瘤的发生和发展过程中协同作用;Ki67及VEGF的表达与乳腺淋巴结转移是影响乳腺癌预后的重要因素。

Objective To investigate the correlations between the lymph node status and the expressions of VEGF,Ki67 in the tissues from patients with breast cancer. Methods hnmunohistochemical method was used to detect the expression of VEGF and Ki 67 in the tissues from 125 patients with breast carcinoma. Results 72.8% patients had node metastasis. The posi- tive rate of VEGF and Ki67 was 56.8% and 74.4% , respectively. The expression of VEGF was positively correlated to that of Ki67 ;Node metastasis was positively correlated to the expression of VEGF,but not to the expression of Ki67. Conclusion VEGF and Ki67 may be synergically involved in the oneogenesis and development of breast carcinoma. The expressions of VEGF and Ki67, as well as node metastasis are the prognostic factors in patients with breast cancer.