稳心颗粒对急性心肌梗死者心率震荡的影响

The Influence of Naoxintong Capsule on Heart Rate Turbulence In Acute Myocardial Infarction

目的探讨稳心颗粒(以下简称"本药")对急性心肌梗死(AMI)心肌缺血和心率震荡(HRT)的影响。方法治疗组(A组):100例AMI者在标准药物治疗基础上开始服用本药。对照组(B组):78例仅进行标准药物治疗。1月后,进行24h动态心电图(DCG)检查,观察对心肌缺血、室性心律失常和HRT的影响。结果①治疗1月后,有症状和无症状的ST段压低及其持续时间以及室性早搏(PVS)总数,两组均有明显改善,与治疗前比较,差异有统计学意义(P<0.05或P<0.01)。A组明显优于B组(P<0.05或P<0.01)。②两组HRT指标(TO、TS、TT)治疗后亦明显改善(P<0.01,P<0.05),且A组明显优于B组(P<0.05或P<0.01)。结论本药能稳定患者自主神经功能,明显改善HRT指标,减少AMI者室性异位搏动、心肌缺血的发生次数,改善其预后。

Objective To explore the therapeutic efficacy of Naoxintong capsule （NC） on isehemia myocardial and Heart Rate Turbulence in acute myocardial infarction disease. Methods A group （ n = 100） was treated with NC and routine treatment. B group （ n = 78） was treated with routine treatment for one month. The isehemia myocardial and HRT were observed by dynamic electrocardiogram before and after treatment. Results ①Frequency and sustained time of symptomatic and asymtomatic myocardial ischemia and ventricular premature beat were decreased significantly in two groups （ P 〈 0.05 or P 〈 0.01 respectively） after therapy, but they decreased more significantly in A group than in B group （ P 〈 0.05 or P 〈 0.01 ）. ②HRT in A group was improved after treatment （ P 〈 0.01 ）, and it is superior to B group （ P 〈 0.01 ）. No serious side effects were found in A group. Conclusion NC mend autonomic nervous system ,improve myocardial ischemia and HRT,ameliorate prognosis of patients with acute myocardial infarction.