急性腔隙性脑梗死认知功能障碍的危险因素研究

Investigation of relative risk factors of vascular cognitive impairment of first-ever lacunar infarction

目的研究初次发病的腔隙性脑梗死(lacunar infarction,LI)患者认知功能障碍的发病率及相关危险因素。方法前瞻性选取首次发病、病程<2周的LI患者,发病72h内应用简易智力状态检查量表(mini-mental state examination,MMSE)对LI患者进行认知功能评定。结果60例患者中21例(35%)出现了不同程度的认知功能障碍。Logistic回归分析显示LI患者认知功能障碍的出现与高血压、糖尿病、高脂血症及高同型半胱氨酸(HHcy)有关(P<0.05)。结论首次发病的LI常可出现认知功能障碍,高血压、糖尿病、高脂血症及HHcy与认知功能障碍的关系密切。

Objective To explore the incidence rate and relative risk factors of cognitive impairment of the first-ever lacunar infarction. Methods Sixty patients with first attack of LI, whose course of disease was less than 2 weeks, were selected in the prospective cohort study, first-ever diagnosed LI patients underwent MMSE within 72h. Results Twenty-one LI patients experienced cognitive impairment（35%）. By Logistic regression analysis, the result showed that the onsets of cognitive impairment had correlation with hypertension, diabetes mellitus, hyperlipoidemia and HHcy（P〈0.05）. Conclusion First-ever lacunar infarction usually lead to vascular cognitive impairment. It is elosety related to multiple factors, such as hypertension, diabetes mellitus, hyperlipoidemia and HHcy.