银杏达莫注射液对急性脑梗死患者血清高敏C反应蛋白及神经功能的影响

Effects of Ginkgo dipyridolum injection on high sensitivity C-reactive protein and neurofunction in patients with acute cerebral infarction

目的观察急性脑梗死患者使用银杏达莫前后血清高敏C反应蛋白(high sensitive C-reaction protein,hs-CRP)水平的变化及对神经功能的改善作用,探讨银杏达莫对急性脑梗死患者的疗效及可能机制。方法选择80例急性脑梗死患者随机分为治疗组和对照组各40例,银杏达莫(40例)给予银杏达莫注射液20ml溶于生理盐水250ml静滴,对照组(40例)给予丹参粉针400mg溶于生理盐250ml静滴,1次/d。连用15d。于治疗前后分别应用放射免疫比浊法检测治疗前和治疗后7d、15d的血清hs-CRP水平变化,且分别进行神经功能缺损程度评分。结果2组hs-CRP水平在梗死后7d最高,随后逐渐降低。治疗组治疗前血清hs-CRP水平和神经功能缺损评分与对照组比较差异无统计学意义(P>0.05);治疗后7d及15d治疗组hs-CRP水平神经功能缺损总分均低于对照组(P<0.01)。结论银杏达莫可降低患者血清hs-CRP水平,减轻炎症反应,改善缺损的神经功能。通过降低血清hs-CRP水平可能是其作用机制之一。

Objective To explore the effects of Ginkgo dipyridolum injection on high sensitivity C-reactive protein and neurofunction in patients with acute cerebral infarction. Methods Eighty patients with cerebral infarction were divided into two groups randomly. In treatment group（n=40）, the patients were treated with 20 ml Ginkgo dipyridolum injection plus 250ml saline intravenously,once a day. Forty patients in control group were treated with radix injection 400 mg plus 250 ml saline intravenously, once a day. All treatment lasted for 15 days. The neurologie impairment scores were noted down and concentrations of soluble hs-CRP before the treatment and at 7d and 15d after the treatment. The level of serum hs-CRP was measured by scatter immune turbidity method. Results hs-CRP reached the highest level at 7d and then decreased slowly. The decline in serum level of hs-CRP at 7d and 15d of the treatment was more significant in the patients of treatment group than that in controlgroup（P〈0.01）. The decline of the neurologic impairment scores at 7d and 15d of the treatment was more significant in the patients of treatment group than that of control group（P〈0.01）. Conclusion Ginkgo dipyridolum injection can decrease serum hs-CRP and abate inflammatory reaction as well as improving impaired neurofunctions. Decreasing the level of serum hs-CRP may be one of the mechanisms of its effect.