二氢丹参酮Ⅰ对H22肝癌荷瘤小鼠的放射增敏作用

The Radiosensitizing Effects of Dihydrotanshinone Ⅰ on H22 Hepatoma-bearing Mices

目的探讨二氢丹参酮Ⅰ对荷H22肝癌小鼠的放射增敏作用。方法建立小鼠H22肝癌模型,分为空白对照组、单纯照射组、阳性对照组、二氢丹参酮I(高、中、低)组。经照射后,观察荷瘤鼠肿瘤生长状况,记录肿瘤照射后生长时间,计算肿瘤生长延缓时间和增敏系数(EF)。照后22d处死小鼠,剥瘤称重,计算抑瘤率。结果给药二氢丹参酮Ⅰ(高、中、低)组与空白组相比,均能抑制肿瘤生长,且中、高剂量具有一定的放射增敏作用,增敏系数分别为1.43、1.66。结论二氢丹参酮I对H22肝癌小鼠肿瘤生长有抑制作用,且有一定的放射增敏效果。

Objective To investigate the radiosensitizing effects of dibydrotanshinone I on H22 hepatoma - bearing mice. Methods To establish the mouse hepatoma H22 models which were divided into blank control group, pure radiation group, positive control group, dihydrotanshinone I（high, medium and low） groups. After irradiated, observe the growth of tumor＇ s conditions, record epigenetic tumor irradiation time, calculated the delay time of tumor growth and enhancement factor （EF）. After 22 days, the mice were killed, tumors stripped and the inhibition rate calculate. Results Dihydrotansbinone I （high, medium and low） groups inhibited the tumor growth better than the blank group,and dihydrotanshinone I （medium and high） group had the significant radiosensitizing effect. The enhancement factor Was 1.43,1.66, respectively. Conclusion Dihydrotanshinone I can inhibite the tumor growth and has the radiosensitizing effects on H22 hepatoma- beating mice.