2-(氨基苯基)六氟异丙醇衍生物的合成

Synthesis of 2-Amino Phenyl Hexafluoroisoropanols

以六氟丙酮三水合物和芳香胺为原料,合成了一系列2-(氨基苯基)六氟异丙醇化合物。研究了原料配比、催化剂种类及用量、溶剂种类、反应时间及取代基对反应的影响。结果表明,在六氟丙酮三水合物用量为90mmol、芳香胺用量为30mmol、对甲基苯磺酸为催化剂、其用量为苯胺物质量的6%时,回流反应5～35h,反应的转化率和收率分别高达40%～100%和39%～99%。推测了六氟丙酮三水合物与苯胺的反应历程,通过对其中间产物结构的表征进一步确认了反应历程。

A series of 2-amino phenyl hexafluoroisopropanols were prepared from HFA·3H2O and anilines. The effects of the mole ratio of HFA ·3H2O and aniline, catalyst, solvent, reaction time and substituent on the reaction were investigated. The optimum reaction conditions were selected as follows： 90 mmol of HFA ·3H2O, 30 mmol of aromatic amine, a mole fraction of TsOH of 6% based on aniline, reflux for 5-35 h. Under these conditions, the conversion and yield were respectively 40% - 100% and 39% -99%. The reaction mechanism of aniline and HFA ·3H2O was discussed.