铜绿假单胞菌临床分离株感染分布与耐药性分析

Distribution and drug resistance of clinically isolated Pseudomonas aeruginosa strains

目的探讨铜绿假单胞菌临床分离株的感染分布情况及其耐药性与耐药趋势,方法对2005年7月～2007年7月本院各科室送检合格临床标本进行常规细菌分离培养与鉴定、进行药物敏感性测试,统计分析其院内感染的分布及耐药性。结果共检出204株铜绿假单胞菌。感染部位依次为呼吸道、伤口等在感染患者中,以老年患者为主,主要分布在ICU病房,3年间铜绿假单胞菌对18种常用抗生素耐药率存在普遍增高的趋势。18种抗菌药物中耐药率最高的是头孢呋辛、头孢噻肟钠和四环素,高达90%以上;敏感性最强的是亚胺培南和环丙沙星,敏感率为92.65%和87.25%。结论:本院铜绿假单胞菌分布以呼吸道和伤口感染为主,患者多为老年人。铜绿假单胞菌与院内感染密切相关,且耐药性严重,表现为多重耐药。加强耐药性监测,合理选用抗生素,以减少耐药菌株的出现与传播至关重要。

Objective To survey the tribution and drug resistance of Pseudomonas Aeruginosa isolates. Methods -B method was used to determine the resistance of clinical isolated and cultured Pseudomonas Aeruginosa isoaltes in July 2005 to July 2007. Results There 204 Pseudomonas aeruginosa strains were isolated. The infection sites were respiratory tract, wound surface ere, being in the deseendding orders of sputum （ 105strains, 51.47 %）, pundence （67strains, 32.84% ）, secretory juice （17strains,8.33%）,urine （Sstrains,3.92%） and blood （4 strains , 1 .96% ）.The infection rate in those above age of 56 year old was 46.08% and 84 strains were isolated from department of ICU. Pseudomonas aeruginosa was highly resistant to 18 commonly used antibiotics .The drug resistance rates of Pseudomonas Aeruginosa were increased rapidly by years. The resistance to cefuroxime ,cefotaxime sodium and ambramycin was over 90% .The most sensitive drug was imipenem and ciprofloxacin （92.65% ,87.25%）. Conclusion Pseudomonas aeruginosa is closely associated with hospital infection and drug resistance rate is high. Thus drug resistance monitoring and rantional use of antibiotics are indicated.