慢性阻塞性肺疾病患者血浆内皮素-1含量与肺功能变化的研究

The study on the change of plasma endothelin-1 related with pulmonary function in patients with chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺疾病（COPD）患者血浆内皮素（ET）-1含量与肺功能变化的关系。方法选择健康体检者30例为A组，选择34例COPD急性发作期患者为B组，患者治疗后病情缓解期为c组，分别在治疗前后测定血浆ET-1含量，并行动脉血气及肺功能检查。结果B、c组患者血浆ET-1含量显著高于A组，与PaO2呈负相关，且与PaCO：呈正相关，P值均〈0．01。B组患者肺功能参数（VC、FEV1/WVC、MVV、V50、V25）明显低于A组和c组[分别为（55.3±24．5）％、（54．8±19．3）％、（54．2±16．2）％、（54．8±9．9）％、（58．7±14．5）％与（114．8±24．1）％、（84．9±21．6）％、（86．4±17．2）％、（78．5±14．8）％、（90．3±15．4）％和（110．1±19．4）％、（85．8±15．5）％、（85．9士16．7）％、（74．5±13．4）％、（89．4±18．6）％]，P值均〈0．01。结论血浆ET．1、缺氧、C02潴留共同参与COPD病理生理的调节作用，从而影响肺功能变化。

Objective To explore the relationship of content of plasma endothelin （ET）-I with the change of pulmonary function in patients with chronic obstructive pulmonary disease （COPD）. Method Thirty cases of the normal people were as group A, 34 cases of the patients with COPD with acute exacerbation before treatment were as group B and the patients with remission period after treatment were as group C, the plasma ET-1, arterial blood gas and pulmonary function parameters were determined from the patients before and after treatment. Results The plasma ET-1 in group B and group C were significantly higher than that in group A, the content of the plasma ET-1 had negatively correlated with PaO2, and that had positively correlated with PaCO2, P〈 0.01. The pulmonary function parameters （VC, FEV1/FVC, MVV, V50, V25） in group B were significantly lower than those in group A and group C [ （55.3 ± 24.5）%,（54.8 ± 19.3）%,（54.2 ± 16.2）%, （54.8 ±9.9）%,（58.7 ± 14.5）%; （114.8 ±24.1）%,（84.9 ± 21.6）%,（86.4 ± 17.2）%,（78.5 ± 14.8）%, （90.3 ± 15.4）% and （110.1 ± 19.4）%,（85.8 ± 15.5）%,（85.9 ± 16.7）%,（74.5 ± 13.4）%,（89A ± 18.6）%, respectively], P 〈 0.01. Conclusion Pathophysiological effects of patients with COPD can be commonly adjusted by the plasma ET-1, oxygen and carbon dioxide retention, which affect pulmonary function.