血清抵抗素和白细胞介素18检测预测宫内感染的价值

The relationships between serum interleukin-18 and resistin for predicting intraamniotic infection

目的检测自细胞介素18（IL-18）和抵抗素在早产妊娠妇女血清中的含量，以探讨上述指标预测宫内感染的价值。方法选取早产妊娠妇女43例作为宫内感染组，选取同期进行产前检查的健康妊娠妇女40例作为对照组。分别抽取空腹静脉血进行IL．18和抵抗素含量的检测。结果宫内感染组IL-18的含量[（38．7±10．4）μg/L]高于对照组[（23．5±5．6）μg/L]，差异有统计学意义（P〈0．01）；宫内感染组抵抗素的含量[（24．84±5．32）μg/L]高于对照组[（17．32±5．15）μg/L]，差异有统计学意义（P〈0．01）；IL-18和抵抗素呈正相关关系（r=0．61，P〈0．01）。结论IL-18和抵抗素的含量在宫内感染的妊娠妇女中存在显著性变化，可作为预测宫内感染的辅助诊断指标。

Objective To study the relationships between serum interleukin-18（IL-18） and resisfin for predicting intraamniotie infection. Method Serum levels of IL-18 and resistin were measured in 43 pregnant women with intraamniotie infection （infection group） and 40 normal pregnant women （control group）. Results The level of IL-18 in infection group[ （38.7± 10.4） μg/L] was higher than that in control group [ （23.5 ± 5.6） μg/L], there was significant difference between two groups （P 〈 0.01 ）. The level of resistin in infection group [ （24.84 ± 5.32） μg/L] was higher than that in control group [ （17.32 ± 5.15 ） μg/L], there was significant difference between two groups （P 〈 0.01 ）. The levels of resistin and IL-18 were correlated in pregnant women with intraamniotie infection （r = 0.61, P 〈 0.01 ）. Conclusion Detecting the levels of IL-18 and resistin in pregnant women earl identify intraarnniotie infection.