摘要
目的探讨腹部手术患者罗库溴铵靶控输注的有效维持浓度。方法60例ASAⅡ级、择期全麻腹部手术患者,随机分成A、B、C三组,每组20例。根据预实验结果,将三组诱导插管时效应室靶浓度(Ce)均设置为3μg/ml,术中维持Ce分别为0.6、0.8、1.0μg/ml。观察各组诱导插管、术中肌松维持和术后肌松恢复情况。结果三组均可顺利完成气管插管;术中肌松维持,0.6μg/ml组(A组)肌松满意率低,0.8μg/ml组(B组)和1.0μg/ml组(C组)均可维持满意肌松,但1.0μg/ml组罗库溴铵用量更大、术中肌肉阻滞程度较深、术后恢复时间延长(P<0.05)。结论腹部手术患者诱导插管时罗库溴铵Ce设置为3μg/ml、术中Ce维持在0.8μg/ml,可以实现诱导插管顺利、术中肌松满意和术毕迅速恢复的目的。
Objective To investigate the optimum concentration of rocuronium for target controlled infusion （TCI） infusion in patients＇operation on abdominal region. Methods Sixty patients（ASA grade Ⅱ ）scheduled for operation on abdominal region under general anesthesia were studied. The patients were randomly divided into three groups, A, B and C, with 20 cases in each group. The target effective site concentration （Ce） of rocuronium for intubation was 3 μg/ml in each group, and the Ce during operation were O. 6,0.8 and 1.0 μg/ml in A, B and C group respectively. Results Suc- cessful intubation condition was obtained in three groups. Neuromuscular blockade during operation was satisfactory in B and C groups, but not in group A. The Rocuronium consumption, muscle relaxation during surgery and recovery time to 25% of T1 of C group were more than those in group B （P 〈 0.05）. Conclusions The dosage regimen of group B is more suitable for patients＇operation on abdominal region.
出处
《医学信息（内.外科版）》
2009年第8期691-693,共3页
Medical Information Operations Sciences Fascicule
